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Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1

Overview of attention for article published in Development (09501991), February 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

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Title
Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1
Published in
Development (09501991), February 2015
DOI 10.1242/dev.122184
Pubmed ID
Authors

Liang Zhao, Terje Svingen, Ee Ting Ng, Peter Koopman

Abstract

Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan species. However, this role is fulfilled in mammals by Sry, a newly evolved gene on the Y chromosome, such that Dmrt1 has become dispensable for primary sex determination and instead maintains Sertoli cell phenotype in postnatal testes. Here, we report that enforced expression of Dmrt1 in XX mouse fetal gonads using a Wt1-BAC transgene system is sufficient to drive testicular differentiation and male secondary sex development. XX transgenic fetal gonads showed typical testicular size and vasculature. Key ovarian markers, including Wnt4 and Foxl2, were repressed. Sertoli cells expressing the hallmark testis-determining gene Sox9 were formed, although they did not assemble into normal testis cords. Other bipotential lineages differentiated into testicular cell types, including steroidogenic fetal Leydig cells and non-meiotic germ cells. As a consequence, male internal and external reproductive organs developed postnatally, with an absence of female reproductive tissues. These results reveal that Dmrt1 has retained its ability to act as the primary testis-determining trigger in mammals, even though this function is no longer normally required. Thus, Dmrt1 provides a common thread in the evolution of sex determination mechanisms in metazoans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Unknown 112 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 17%
Researcher 17 15%
Student > Master 16 14%
Professor > Associate Professor 14 12%
Student > Bachelor 9 8%
Other 26 23%
Unknown 13 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 40%
Biochemistry, Genetics and Molecular Biology 40 35%
Medicine and Dentistry 6 5%
Arts and Humanities 1 <1%
Veterinary Science and Veterinary Medicine 1 <1%
Other 3 3%
Unknown 17 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 81. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2022.
All research outputs
#523,938
of 25,374,647 outputs
Outputs from Development (09501991)
#94
of 9,469 outputs
Outputs of similar age
#6,166
of 270,187 outputs
Outputs of similar age from Development (09501991)
#4
of 112 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,469 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,187 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.