↓ Skip to main content

Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues

Overview of attention for article published in European Journal of Nutrition, March 2018
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 X users

Citations

dimensions_citation
43 Dimensions

Readers on

mendeley
57 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues
Published in
European Journal of Nutrition, March 2018
DOI 10.1007/s00394-018-1680-7
Pubmed ID
Authors

Marija Lesjak, Sara Balesaria, Vernon Skinner, Edward S. Debnam, Surjit Kaila S. Srai

Abstract

There is general agreement that some dietary polyphenols block non-haem iron uptake, but the mechanisms by which they achieve this action are poorly understood. Since the polyphenol quercetin is ingested daily in significant amounts, we have investigated the effect of quercetin on duodenal non-haem iron absorption in vivo, as well as its effect on factors known to be involved in systemic iron metabolism. Rats were subject to gastric gavage and systemic quercetin administration. Treatments were followed with uptake studies using radiolabeled iron, serum iron and transferrin saturation measurements, LC-MS/MS analysis of quercetin metabolites in serum, determination of tissue non-haem iron content and analysis of gene expression of iron-related proteins. Both oral and intraperitoneal (IP) quercetin caused serum and tissue iron depletion by two means, first by increasing mucosal iron uptake and inhibiting iron efflux from duodenal mucosa, and second by decreasing levels of duodenal DMT1, Dcytb and FPN. Additionally, IP quercetin induced highly significant increased liver expression of hepcidin, a hormone known to inhibit intestinal iron uptake. Oral quercetin significantly inhibited iron absorption, while IP quercetin significantly affected iron-related genes. These results could lead to development of new effective ways of preventing and treating iron deficiency anaemia, the most widespread nutritional disorder in the world.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Student > Bachelor 8 14%
Student > Master 5 9%
Researcher 4 7%
Professor 3 5%
Other 9 16%
Unknown 17 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 21%
Medicine and Dentistry 9 16%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Unspecified 2 4%
Nursing and Health Professions 2 4%
Other 5 9%
Unknown 23 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2023.
All research outputs
#14,963,897
of 23,934,148 outputs
Outputs from European Journal of Nutrition
#1,662
of 2,488 outputs
Outputs of similar age
#190,423
of 332,866 outputs
Outputs of similar age from European Journal of Nutrition
#50
of 76 outputs
Altmetric has tracked 23,934,148 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,488 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,866 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.