| Title |
Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention
|
|---|---|
| Published in |
Current Osteoporosis Reports, February 2018
|
| DOI | 10.1007/s11914-018-0424-1 |
| Pubmed ID | |
| Authors |
Vihitaben S. Patel, M. Ete Chan, Janet Rubin, Clinton T. Rubin |
| Abstract |
Changes in the bone marrow microenvironment, which accompany aging and obesity, including increased marrow adiposity, can compromise hematopoiesis. Here, we review deleterious shifts in molecular, cellular, and tissue activity and consider the potential of exercise to slow degenerative changes associated with aging and obesity. While bone marrow hematopoietic stem cells (HSC) are increased in frequency and myeloid-biased with age, the effect of obesity on HSC proliferation and differentiation remains controversial. HSC from both aged and obese environment have reduced hematopoietic reconstitution capacity following bone marrow transplant. Increased marrow adiposity affects HSC function, causing upregulation of myelopoiesis and downregulation of lymphopoiesis. Exercise, in contrast, can reduce marrow adiposity and restore hematopoiesis. The impact of marrow adiposity on hematopoiesis is determined mainly through correlations. Mechanistic studies are needed to determine a causative relationship between marrow adiposity and declines in hematopoiesis, which could aid in developing treatments for conditions that arise from disruptions in the marrow microenvironment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 78 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Student > Bachelor | 13 | 17% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 25 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 19% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Immunology and Microbiology | 6 | 8% |
| Agricultural and Biological Sciences | 4 | 5% |
| Sports and Recreations | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 30 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2018.
All research outputs
#18,603,172
of 23,043,346 outputs
Outputs from Current Osteoporosis Reports
#404
of 550 outputs
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#256,754
of 330,336 outputs
Outputs of similar age from Current Osteoporosis Reports
#11
of 20 outputs
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