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Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography study

Overview of attention for article published in Journal of Psychopharmacology, September 2011
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Title
Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography study
Published in
Journal of Psychopharmacology, September 2011
DOI 10.1177/0269881111415730
Pubmed ID
Authors

NJ Kalk, J Melichar, RB Holmes, LG Taylor, MRC Daglish, S Hood, T Edwards, A Lennox-Smith, AR Lingford-Hughes, DJ Nutt

Abstract

Generalized Anxiety Disorder (GAD) may involve hypo-responsiveness of noradrenaline a2 receptors. To test this hypothesis, we used (99m)Tc-hexa-methyl-propylene-amine-oxime (HMPAO) Single Photon Emission Computed Tomography to measure regional cerebral perfusion in patients with untreated GAD, venlafaxine-treated patients and healthy controls during word generation before and after clonidine. Concurrent psychological and physiological measures supported noradrenergic hypofunction in GAD in some cases. A single-day split-dose technique was used. Images were processed using SPM5 (Institute of Neurology). Factorial analysis revealed no significant results. Exploratory analyses were done. Regional perfusion during verbal fluency differed by group pre-clonidine. Compared with healthy controls, patients with untreated GAD displayed increased perfusion in the left Broca's area and left occipitotemporal region. Treated GAD patients displayed increased cerebellar perfusion bilaterally. Clonidine was associated with different changes in cerebral perfusion in each group. Increases were seen in the right supra-marginal gyrus in healthy subjects, in the left pre-central gyrus in treated GAD patients and in the right cerebellum and middle frontal gyrus in untreated GAD patients. Despite these differences, the findings were not consistent with a noradrenergic hypo-responsiveness hypothesis, as the treated group showed a different pattern of response rather than a normalization of response.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 22%
Researcher 5 19%
Student > Master 3 11%
Student > Ph. D. Student 2 7%
Student > Postgraduate 2 7%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Psychology 11 41%
Medicine and Dentistry 4 15%
Neuroscience 2 7%
Environmental Science 1 4%
Agricultural and Biological Sciences 1 4%
Other 0 0%
Unknown 8 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2011.
All research outputs
#20,145,561
of 22,651,245 outputs
Outputs from Journal of Psychopharmacology
#1,719
of 1,923 outputs
Outputs of similar age
#119,734
of 130,159 outputs
Outputs of similar age from Journal of Psychopharmacology
#31
of 31 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.