Title |
Thyroid Hormones and Cardiovascular Function and Diseases
|
---|---|
Published in |
JACC, April 2018
|
DOI | 10.1016/j.jacc.2018.02.045 |
Pubmed ID | |
Authors |
Salman Razvi, Avais Jabbar, Alessandro Pingitore, Sara Danzi, Bernadette Biondi, Irwin Klein, Robin Peeters, Azfar Zaman, Giorgio Iervasi |
Abstract |
Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality. Experimental data and small clinical trials have suggested a beneficial role of TH in ameliorating CV disease. The aim of this review is to provide clinicians dealing with CV conditions with an overview of the current knowledge of TH perturbations in CV disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 18 | 12% |
Spain | 17 | 11% |
Colombia | 10 | 6% |
Venezuela, Bolivarian Republic of | 8 | 5% |
Mexico | 8 | 5% |
Brazil | 3 | 2% |
United Kingdom | 3 | 2% |
Italy | 3 | 2% |
Canada | 3 | 2% |
Other | 25 | 16% |
Unknown | 56 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 103 | 67% |
Practitioners (doctors, other healthcare professionals) | 28 | 18% |
Scientists | 17 | 11% |
Science communicators (journalists, bloggers, editors) | 6 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 346 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 45 | 13% |
Researcher | 37 | 11% |
Student > Ph. D. Student | 25 | 7% |
Other | 23 | 7% |
Student > Master | 22 | 6% |
Other | 49 | 14% |
Unknown | 145 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 118 | 34% |
Biochemistry, Genetics and Molecular Biology | 22 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 4% |
Nursing and Health Professions | 11 | 3% |
Agricultural and Biological Sciences | 8 | 2% |
Other | 21 | 6% |
Unknown | 153 | 44% |