| Title |
Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules
|
|---|---|
| Published in |
Pediatric Nephrology, October 2011
|
| DOI | 10.1007/s00467-011-2029-0 |
| Pubmed ID | |
| Authors |
Christopher Y. Lu, Pamela D. Winterberg, Jianlin Chen, John R. Hartono |
| Abstract |
Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia-reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal-spatial roles and potential therapeutics targeting this particular receptor-ligand interaction are also explored. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 3% |
| China | 1 | 3% |
| Unknown | 33 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 6 | 17% |
| Researcher | 5 | 14% |
| Other | 4 | 11% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Master | 3 | 9% |
| Other | 5 | 14% |
| Unknown | 8 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 40% |
| Agricultural and Biological Sciences | 8 | 23% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Psychology | 2 | 6% |
| Computer Science | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 5 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2015.
All research outputs
#20,264,045
of 22,794,367 outputs
Outputs from Pediatric Nephrology
#3,292
of 3,537 outputs
Outputs of similar age
#129,272
of 140,951 outputs
Outputs of similar age from Pediatric Nephrology
#26
of 30 outputs
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So far Altmetric has tracked 3,537 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.