You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
|
|---|---|
| Published in |
Molecular Psychiatry, March 2015
|
| DOI | 10.1038/mp.2015.12 |
| Pubmed ID | |
| Authors |
T-K Clarke, M K Lupton, A M Fernandez-Pujals, J Starr, G Davies, S Cox, A Pattie, D C Liewald, L S Hall, D J MacIntyre, B H Smith, L J Hocking, S Padmanabhan, P A Thomson, C Hayward, N K Hansell, G W Montgomery, S E Medland, N G Martin, M J Wright, D J Porteous, I J Deary, A M McIntosh |
| Abstract |
Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few studies have examined the genetic overlap between cognitive ability and ASD/ADHD. The aim of this study was to examine the polygenic overlap between ASD/ADHD and cognitive ability in individuals from the general population. Polygenic risk for ADHD and ASD was calculated from genome-wide association studies of ASD and ADHD conducted by the Psychiatric Genetics Consortium. Risk scores were created in three independent cohorts: Generation Scotland Scottish Family Health Study (GS:SFHS) (n=9863), the Lothian Birth Cohorts 1936 and 1921 (n=1522), and the Brisbane Adolescent Twin Sample (BATS) (n=921). We report that polygenic risk for ASD is positively correlated with general cognitive ability (beta=0.07, P=6 × 10(-7), r(2)=0.003), logical memory and verbal intelligence in GS:SFHS. This was replicated in BATS as a positive association with full-scale intelligent quotient (IQ) (beta=0.07, P=0.03, r(2)=0.005). We did not find consistent evidence that polygenic risk for ADHD was associated with cognitive function; however, a negative correlation with IQ at age 11 years (beta=-0.08, Z=-3.3, P=0.001) was observed in the Lothian Birth Cohorts. These findings are in individuals from the general population, suggesting that the relationship between genetic risk for ASD and intelligence is partly independent of clinical state. These data suggest that common genetic variation relevant for ASD influences general cognitive ability.Molecular Psychiatry advance online publication, 10 March 2015; doi:10.1038/mp.2015.12. |
X Demographics
The data shown below were collected from the profiles of 112 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 18 | 16% |
| United Kingdom | 15 | 13% |
| United States | 11 | 10% |
| Spain | 4 | 4% |
| Ireland | 3 | 3% |
| Finland | 3 | 3% |
| Turkey | 2 | 2% |
| Netherlands | 2 | 2% |
| Mongolia | 1 | <1% |
| Other | 5 | 4% |
| Unknown | 48 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 94 | 84% |
| Scientists | 11 | 10% |
| Practitioners (doctors, other healthcare professionals) | 6 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 349 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| France | 2 | <1% |
| United Kingdom | 2 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 337 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 65 | 19% |
| Researcher | 54 | 15% |
| Student > Master | 49 | 14% |
| Student > Bachelor | 35 | 10% |
| Professor > Associate Professor | 15 | 4% |
| Other | 57 | 16% |
| Unknown | 74 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 78 | 22% |
| Agricultural and Biological Sciences | 47 | 13% |
| Biochemistry, Genetics and Molecular Biology | 40 | 11% |
| Medicine and Dentistry | 35 | 10% |
| Neuroscience | 27 | 8% |
| Other | 36 | 10% |
| Unknown | 86 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 240. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2023.
All research outputs
#159,920
of 25,784,004 outputs
Outputs from Molecular Psychiatry
#143
of 4,671 outputs
Outputs of similar age
#1,699
of 275,222 outputs
Outputs of similar age from Molecular Psychiatry
#3
of 60 outputs
Altmetric has tracked 25,784,004 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,671 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,222 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.