| Title |
Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model
|
|---|---|
| Published in |
Metabolomics, July 2014
|
| DOI | 10.1007/s11306-014-0711-5 |
| Pubmed ID | |
| Authors |
Roel Van Assche, Liesbet Temmerman, Daniel A. Dias, Berin Boughton, Kurt Boonen, Bart P. Braeckman, Liliane Schoofs, Ute Roessner |
| Abstract |
Despite decades of research, no early-onset biomarkers are currently available for Alzheimer's disease, a cureless neurodegenerative disease afflicting millions worldwide. In this study, transgenic Caenorhabditis elegans were used to investigate changes in the metabolome after induced expression of amyloid-β. GC- and LC-MS-based platforms determined a total of 157 differential features. Some of these were identified using in-house (GC-MS) or public libraries (LC-MS), revealing changes in allantoin, cystathionine and tyrosine levels. Since C. elegans is far better suited to metabolomics studies than most other model systems, the accordance of these findings with vertebrate literature is promising and argues for further use of C. elegans as a model of human pathology in the study of AD. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 25% |
| United Kingdom | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Belgium | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Researcher | 15 | 18% |
| Student > Master | 11 | 13% |
| Student > Bachelor | 8 | 10% |
| Other | 4 | 5% |
| Other | 11 | 13% |
| Unknown | 19 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 27% |
| Biochemistry, Genetics and Molecular Biology | 14 | 17% |
| Chemistry | 9 | 11% |
| Neuroscience | 6 | 7% |
| Computer Science | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 21 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2016.
All research outputs
#13,043,508
of 23,339,727 outputs
Outputs from Metabolomics
#572
of 1,309 outputs
Outputs of similar age
#102,938
of 230,045 outputs
Outputs of similar age from Metabolomics
#17
of 41 outputs
Altmetric has tracked 23,339,727 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,309 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,045 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.