| Title |
Vasopressin and the regulation of aquaporin-2
|
|---|---|
| Published in |
Clinical and Experimental Nephrology, April 2013
|
| DOI | 10.1007/s10157-013-0789-5 |
| Pubmed ID | |
| Authors |
Justin L. L. Wilson, Carlos A. Miranda, Mark A. Knepper |
| Abstract |
Water excretion is regulated in large part through the regulation of osmotic water permeability of the renal collecting duct epithelium. Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2). Two processes contribute: (1) regulation of AQP2 trafficking to the apical plasma membrane; and (2) regulation of the total amount of the AQP2 protein in the cells. Regulation of AQP2 abundance is defective in several water-balance disorders, including many polyuric disorders and the syndrome of inappropriate antidiuresis. Here we review vasopressin signaling in the renal collecting duct that is relevant to the two modes of water permeability regulation. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 22% |
| Researcher | 14 | 14% |
| Student > Ph. D. Student | 14 | 14% |
| Student > Doctoral Student | 10 | 10% |
| Student > Master | 7 | 7% |
| Other | 7 | 7% |
| Unknown | 27 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 28% |
| Agricultural and Biological Sciences | 19 | 19% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Neuroscience | 6 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 6 | 6% |
| Unknown | 29 | 29% |