Title |
Methylation of miRNA genes and oncogenesis
|
---|---|
Published in |
Biochemistry, February 2015
|
DOI | 10.1134/s0006297915020029 |
Pubmed ID | |
Authors |
V. I. Loginov, S. V. Rykov, M. V. Fridman, E. A. Braga |
Abstract |
Interaction between microRNA (miRNA) and messenger RNA of target genes at the posttranscriptional level provides fine-tuned dynamic regulation of cell signaling pathways. Each miRNA can be involved in regulating hundreds of protein-coding genes, and, conversely, a number of different miRNAs usually target a structural gene. Epigenetic gene inactivation associated with methylation of promoter CpG-islands is common to both protein-coding genes and miRNA genes. Here, data on functions of miRNAs in development of tumor-cell phenotype are reviewed. Genomic organization of promoter CpG-islands of the miRNA genes located in inter- and intragenic areas is discussed. The literature and our own results on frequency of CpG-island methylation in miRNA genes from tumors are summarized, and data regarding a link between such modification and changed activity of miRNA genes and, consequently, protein-coding target genes are presented. Moreover, the impact of miRNA gene methylation on key oncogenetic processes as well as affected signaling pathways is discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 3% |
Russia | 1 | 3% |
Unknown | 30 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 31% |
Student > Ph. D. Student | 6 | 19% |
Student > Bachelor | 5 | 16% |
Student > Master | 4 | 13% |
Lecturer > Senior Lecturer | 1 | 3% |
Other | 3 | 9% |
Unknown | 3 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 34% |
Biochemistry, Genetics and Molecular Biology | 10 | 31% |
Medicine and Dentistry | 2 | 6% |
Environmental Science | 2 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 2 | 6% |
Unknown | 4 | 13% |