Title |
Endogenous retroviruses
|
---|---|
Published in |
Cellular and Molecular Life Sciences, September 2008
|
DOI | 10.1007/s00018-008-8499-y |
Pubmed ID | |
Authors |
R. Tarlinton, J. Meers, P. Young |
Abstract |
Although endogenous retroviruses are ubiquitous features of all mammalian genomes, the process of initial germ line invasion and subsequent inactivation from a pathogenic element has not yet been observed in a wild species. Koala retrovirus (KoRV) provides a unique opportunity to study this process of endogenisation in action as it still appears to be spreading through the koala population. Ongoing expression of the endogenous sequence and consequent high levels of viraemia have been linked to neoplasia and immunosuppression in koalas. This apparently recent invader of the koala genome shares a remarkably close sequence relationship with the pathogenic exogenous Gibbon ape leukaemia virus (GALV), and comparative analyses of KoRV and GALVare helping to shed light on how retroviruses in general adapt to a relatively benign or at least less pathogenic existence within a new host genome. (Part of a multi-author review). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 4% |
Denmark | 1 | 2% |
France | 1 | 2% |
Australia | 1 | 2% |
Unknown | 48 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 32% |
Student > Doctoral Student | 6 | 11% |
Student > Ph. D. Student | 6 | 11% |
Student > Master | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 4 | 8% |
Unknown | 13 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 43% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Veterinary Science and Veterinary Medicine | 3 | 6% |
Immunology and Microbiology | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Other | 2 | 4% |
Unknown | 15 | 28% |