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X Demographics
Mendeley readers
Attention Score in Context
| Title |
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
|
|---|---|
| Published in |
Nature Communications, March 2015
|
| DOI | 10.1038/ncomms7377 |
| Pubmed ID | |
| Authors |
Matthew J. Niederst, Lecia V. Sequist, John T. Poirier, Craig H. Mermel, Elizabeth L. Lockerman, Angel R. Garcia, Ryohei Katayama, Carlotta Costa, Kenneth N. Ross, Teresa Moran, Emily Howe, Linnea E. Fulton, Hillary E. Mulvey, Lindsay A. Bernardo, Farhiya Mohamoud, Norikatsu Miyoshi, Paul A. VanderLaan, Daniel B. Costa, Pasi A. Jänne, Darrell R. Borger, Sridhar Ramaswamy, Toshi Shioda, Anthony J. Iafrate, Gad Getz, Charles M. Rudin, Mari Mino-Kenudson, Jeffrey A. Engelman |
| Abstract |
Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, relapse typically occurs after an average of 1 year of continuous treatment. A fundamental histological transformation from NSCLC to small-cell lung cancer (SCLC) is observed in a subset of the resistant cancers, but the molecular changes associated with this transformation remain unknown. Analysis of tumour samples and cell lines derived from resistant EGFR mutant patients revealed that Retinoblastoma (RB) is lost in 100% of these SCLC transformed cases, but rarely in those that remain NSCLC. Further, increased neuroendocrine marker and decreased EGFR expression as well as greater sensitivity to BCL2 family inhibition are observed in resistant SCLC transformed cancers compared with resistant NSCLCs. Together, these findings suggest that this subset of resistant cancers ultimately adopt many of the molecular and phenotypic characteristics of classical SCLC. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Comoros | 2 | 33% |
| Canada | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 50% |
| Members of the public | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 306 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 303 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 70 | 23% |
| Student > Ph. D. Student | 54 | 18% |
| Student > Bachelor | 20 | 7% |
| Student > Master | 19 | 6% |
| Other | 17 | 6% |
| Other | 45 | 15% |
| Unknown | 81 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 26% |
| Biochemistry, Genetics and Molecular Biology | 63 | 21% |
| Agricultural and Biological Sciences | 45 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 4% |
| Computer Science | 2 | <1% |
| Other | 8 | 3% |
| Unknown | 97 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2022.
All research outputs
#1,458,420
of 25,837,817 outputs
Outputs from Nature Communications
#21,476
of 58,118 outputs
Outputs of similar age
#18,039
of 276,917 outputs
Outputs of similar age from Nature Communications
#240
of 770 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,118 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,917 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 770 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.