| Title |
Synthesis, X-ray crystal structure, DNA/BSA binding, DNA cleavage and cytotoxicity studies of phenanthroline based copper(II)/zinc(II) complexes
|
|---|---|
| Published in |
BioMetals, June 2017
|
| DOI | 10.1007/s10534-017-0028-8 |
| Pubmed ID | |
| Authors |
Qingming Wang, Han Mao, Wenling Wang, Huimin Zhu, Lihui Dai, Yanli Chen, Xinhui Tang |
| Abstract |
Research on copper(II) 1,10-phenanththroline (phen) derivatives continues to attract interest in the context of structure and biological properties. In this paper, two metal complexes [Cu2(phen)2(μ-Cl)2]Cl2 (1), [Zn(phen)2(H2O)Cl]Cl·4H2O (2) were synthesized and characterized. The crystal structures of 1 and 2 were determined by X-ray diffraction. In order to investigate the biological properties of the prepared complexes, spectroscopic and biological studies were performed. Results of X-ray diffraction showed that 1 and 2 form two types of crystal structures in a given system: dinuclear and mono-nuclear complex. The preliminary study on the DNA cleavage activity has shown that 1 under study behaved as the chemical nucleases. The DNA binding interaction of 1 & 2 with CT-DNA has been investigated by UV-Visible and fluorescence emission spectrometry and the apparent binding constant (K app) values are 5.1 × 10(4) and 1.2 × 10(4) M(-1), respectively. In addition, fluorescence spectrometry of bovine serum albumin (BSA) with 1 & 2 showed that the quenching mechanism might be a static quenching procedure with one binding sites for BSA. In addition, the cytotoxicity of 1 in vitro on tumor cells lines (MCF-7, HepG2 and HT29) was examined by MTT and showed better antitumor effect on the tested cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 20% |
| Student > Ph. D. Student | 6 | 20% |
| Student > Master | 4 | 13% |
| Researcher | 3 | 10% |
| Professor | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 6 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 30% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Veterinary Science and Veterinary Medicine | 1 | 3% |
| Business, Management and Accounting | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 6 | 20% |
| Unknown | 10 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2018.
All research outputs
#18,603,172
of 23,043,346 outputs
Outputs from BioMetals
#459
of 647 outputs
Outputs of similar age
#242,251
of 317,572 outputs
Outputs of similar age from BioMetals
#6
of 12 outputs
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