| Title |
A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis
|
|---|---|
| Published in |
Brain Structure and Function, May 2010
|
| DOI | 10.1007/s00429-010-0255-z |
| Pubmed ID | |
| Authors |
Florian Kurth, Karl Zilles, Peter T. Fox, Angela R. Laird, Simon B. Eickhoff |
| Abstract |
Whether we feel sympathy for another, listen to our heartbeat, experience pain or negotiate, the insular cortex is thought to integrate perceptions, emotions, thoughts, and plans into one subjective image of "our world". The insula has hence been ascribed an integrative role, linking information from diverse functional systems. Nevertheless, various anatomical and functional studies in humans and non-human primates also indicate a functional differentiation of this region. In order to investigate this functional differentiation as well as the mechanisms of the functional integration in the insula, we performed activation-likelihood-estimation (ALE) meta-analyses of 1,768 functional neuroimaging experiments. The analysis revealed four functionally distinct regions on the human insula, which map to the social-emotional, the sensorimotor, the olfacto-gustatory, and the cognitive network of the brain. Sensorimotor tasks activated the mid-posterior and social-emotional tasks the anterior-ventral insula. In the central insula activation by olfacto-gustatory stimuli was found, and cognitive tasks elicited activation in the anterior-dorsal region. A conjunction analysis across these domains revealed that aside from basic somatosensory and motor processes all tested functions overlapped on the anterior-dorsal insula. This overlap might constitute a correlate for a functional integration between different functional systems and thus reflect a link between them necessary to integrate different qualities into a coherent experience of the world and setting the context for thoughts and actions. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 38% |
| Canada | 1 | 6% |
| Ireland | 1 | 6% |
| Denmark | 1 | 6% |
| Germany | 1 | 6% |
| Unknown | 6 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 9 | 56% |
| Members of the public | 5 | 31% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 955 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 1% |
| Germany | 12 | 1% |
| Canada | 6 | <1% |
| United Kingdom | 4 | <1% |
| Italy | 3 | <1% |
| Netherlands | 3 | <1% |
| Norway | 2 | <1% |
| France | 2 | <1% |
| Chile | 1 | <1% |
| Other | 7 | <1% |
| Unknown | 902 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 218 | 23% |
| Researcher | 171 | 18% |
| Student > Master | 121 | 13% |
| Student > Bachelor | 71 | 7% |
| Student > Doctoral Student | 60 | 6% |
| Other | 168 | 18% |
| Unknown | 146 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 259 | 27% |
| Neuroscience | 177 | 19% |
| Medicine and Dentistry | 115 | 12% |
| Agricultural and Biological Sciences | 77 | 8% |
| Engineering | 16 | 2% |
| Other | 82 | 9% |
| Unknown | 229 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2021.
All research outputs
#3,016,344
of 25,628,260 outputs
Outputs from Brain Structure and Function
#201
of 2,039 outputs
Outputs of similar age
#11,580
of 105,644 outputs
Outputs of similar age from Brain Structure and Function
#7
of 20 outputs
Altmetric has tracked 25,628,260 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
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