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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates
|
|---|---|
| Published in |
Clinical Materials, April 2018
|
| DOI | 10.1016/j.biomaterials.2018.04.026 |
| Pubmed ID | |
| Authors |
Matthew G. Haugh, Ted J. Vaughan, Christopher M. Madl, Rosanne M. Raftery, Laoise M. McNamara, Fergal J. O'Brien, Sarah C. Heilshorn |
| Abstract |
Dimensionality can have a profound impact on stiffness-mediated differentiation of mesenchymal stem cells (MSCs). However, while we have begun to understand cellular response when encapsulated within 3D substrates, the behavior of cells within macro-porous substrates is relatively underexplored. The goal of this study was to determine the influence of macro-porous topographies on stiffness-mediated differentiation of MSCs. We developed macro-porous recombinant elastin-like protein (ELP) substrates that allow independent control of mechanical properties and ligand chemistry. We then used computational modeling to probe the impact of pore topography on the mechanical stimulus that cells are exposed to within these substrates, and finally we investigated stiffness induced biases towards adipogenic and osteogenic differentiation of MSCs within macro-porous substrates. Computational modeling revealed that there is significant heterogeneity in the mechanical stimuli that cells are exposed to within porous substrates and that this heterogeneity is predominantly due to the wide range of possible cellular orientations within the pores. Surprisingly, MSCs grown within 3D porous substrates respond to increasing substrate stiffness by up-regulating both osteogenesis and adipogenesis. These results demonstrate that within porous substrates the behavior of MSCs diverges from previously observed responses to substrate stiffness, emphasizing the importance of topography as a determinant of cellular behavior. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 7 | 35% |
| United States | 2 | 10% |
| United Kingdom | 1 | 5% |
| Peru | 1 | 5% |
| Tunisia | 1 | 5% |
| Pakistan | 1 | 5% |
| Argentina | 1 | 5% |
| Bahrain | 1 | 5% |
| Unknown | 5 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 65% |
| Scientists | 5 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 27% |
| Researcher | 15 | 14% |
| Student > Master | 13 | 12% |
| Professor | 9 | 8% |
| Student > Bachelor | 8 | 7% |
| Other | 11 | 10% |
| Unknown | 24 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 16 | 15% |
| Biochemistry, Genetics and Molecular Biology | 13 | 12% |
| Materials Science | 12 | 11% |
| Agricultural and Biological Sciences | 9 | 8% |
| Chemical Engineering | 6 | 5% |
| Other | 20 | 18% |
| Unknown | 34 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#2,147,586
of 25,604,262 outputs
Outputs from Clinical Materials
#396
of 10,791 outputs
Outputs of similar age
#42,379
of 324,755 outputs
Outputs of similar age from Clinical Materials
#10
of 157 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,791 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,755 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 157 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.