| Title |
The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells
|
|---|---|
| Published in |
Pharmaceutical Research, November 2013
|
| DOI | 10.1007/s11095-013-1231-0 |
| Pubmed ID | |
| Authors |
Shiguo Zhu, Cecele J. Denman, Zehra S. Cobanoglu, Simin Kiany, Ching C. Lau, Stephen M. Gottschalk, Dennis P. M. Hughes, Eugenie S. Kleinerman, Dean A. Lee |
| Abstract |
Natural killer (NK) cell cytotoxicity correlates with the ligation of activating receptors (e.g., NKG2D) by their ligands (e.g., MHC class I-related chains [MIC] A and B) on target cells. Histone deacetylase inhibitors (HDACi) at high concentrations inhibit tumor growth and can increase NKG2D ligand expression on tumor targets, but are widely regarded as toxic to NK cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Austria | 1 | 1% |
| Unknown | 83 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 23% |
| Student > Ph. D. Student | 17 | 20% |
| Student > Master | 8 | 9% |
| Student > Bachelor | 8 | 9% |
| Professor > Associate Professor | 5 | 6% |
| Other | 13 | 15% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 27% |
| Medicine and Dentistry | 17 | 20% |
| Agricultural and Biological Sciences | 12 | 14% |
| Immunology and Microbiology | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 4 | 5% |
| Unknown | 18 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2022.
All research outputs
#1,976,622
of 23,570,677 outputs
Outputs from Pharmaceutical Research
#76
of 2,893 outputs
Outputs of similar age
#19,219
of 217,762 outputs
Outputs of similar age from Pharmaceutical Research
#1
of 28 outputs
Altmetric has tracked 23,570,677 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,893 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 217,762 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.