| Title |
Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
|
|---|---|
| Published in |
Journal of Medical Case Reports, April 2018
|
| DOI | 10.1186/s13256-018-1629-8 |
| Pubmed ID | |
| Authors |
Toyonobu Tsuda, Hayato Tada, Yoshihiro Tanaka, Naoto Nishida, Taiji Yoshida, Takeshi Sawada, Kenji Sakata, Kenshi Hayashi, Masa-aki Kawashiri, Takeru Oyama, Motoko Sasaki, Nozomu Kurose, Masakazu Yamagishi |
| Abstract |
Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury. We report the clinical and histological features of two contrasting Japanese patients with amiodarone-induced reversible and irreversible hepatotoxicity. One patient with amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, showed a reversible course of liver function and imaging after discontinuation of amiodarone. We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 12% |
| Student > Ph. D. Student | 4 | 9% |
| Professor > Associate Professor | 3 | 7% |
| Lecturer | 2 | 5% |
| Professor | 2 | 5% |
| Other | 9 | 21% |
| Unknown | 18 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 19% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Social Sciences | 2 | 5% |
| Economics, Econometrics and Finance | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 18 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2020.
All research outputs
#13,592,375
of 23,043,346 outputs
Outputs from Journal of Medical Case Reports
#925
of 3,950 outputs
Outputs of similar age
#169,535
of 327,682 outputs
Outputs of similar age from Journal of Medical Case Reports
#21
of 78 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,950 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,682 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.