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Cell sensitivity, non-linearity and inverse effects

Overview of attention for article published in Homeopathy, March 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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21 Facebook pages

Citations

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54 Dimensions

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117 Mendeley
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Title
Cell sensitivity, non-linearity and inverse effects
Published in
Homeopathy, March 2015
DOI 10.1016/j.homp.2015.02.002
Pubmed ID
Authors

Paolo Bellavite, Andrea Signorini, Marta Marzotto, Elisabetta Moratti, Clara Bonafini, Debora Olioso

Abstract

It has been claimed that the homeopathic principle of 'similarity' (or 'similia') and the use of individualized remedies in extremely low doses conflicts with scientific laws, but this opinion can be disputed on the basis of recent scientific advances. Several mechanisms to explain the responsiveness of cells to ultra-low doses and the similarity as inversion of drug effects, have again been suggested in the framework of hormesis and modern paradoxical pharmacology. Low doses or high dilutions of a drug interact only with the enhanced sensitivities of regulatory systems, functioning as minute harmful stimuli to trigger specific compensatory healing reactions. Here we review hypotheses about homeopathic drug action at cellular and molecular levels, and present a new conceptual model of the principle of similarity based on allosteric drug action. While many common drugs act through orthostatic chemical interactions aimed at blocking undesired activities of enzymes or receptors, allosteric interactions are associated with dynamic conformational changes and functional transitions in target proteins, which enhance or inhibit specific cellular actions in normal or disease states. The concept of allostery and the way it controls physiological activities can be broadened to include diluted/dynamized compounds, and may constitute a working hypothesis for the study of molecular mechanisms underlying the inversion of drug effects.

X Demographics

X Demographics

The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Germany 1 <1%
Switzerland 1 <1%
Unknown 114 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 16%
Student > Master 13 11%
Other 11 9%
Student > Bachelor 11 9%
Student > Ph. D. Student 10 9%
Other 30 26%
Unknown 23 20%
Readers by discipline Count As %
Medicine and Dentistry 20 17%
Biochemistry, Genetics and Molecular Biology 18 15%
Agricultural and Biological Sciences 14 12%
Pharmacology, Toxicology and Pharmaceutical Science 11 9%
Nursing and Health Professions 8 7%
Other 18 15%
Unknown 28 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2021.
All research outputs
#1,178,148
of 25,373,627 outputs
Outputs from Homeopathy
#67
of 779 outputs
Outputs of similar age
#14,726
of 274,388 outputs
Outputs of similar age from Homeopathy
#1
of 9 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 779 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,388 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them