| Title |
Loss of Function of Slc20a2 Associated with Familial Idiopathic Basal Ganglia Calcification in Humans Causes Brain Calcifications in Mice
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, August 2013
|
| DOI | 10.1007/s12031-013-0085-6 |
| Pubmed ID | |
| Authors |
Nina Jensen, Henrik Daa Schrøder, Eva Kildall Hejbøl, Ernst-Martin Füchtbauer, João Ricardo Mendes de Oliveira, Lene Pedersen |
| Abstract |
Familial idiopathic basal ganglia calcification (FIBGC) is a neurodegenerative disorder with neuropsychiatric and motor symptoms. Deleterious mutations in SLC20A2, encoding the type III sodium-dependent phosphate transporter 2 (PiT2), were recently linked to FIBGC in almost 50% of the families reported worldwide. Here, we show that knockout of Slc20a2 in mice causes calcifications in the thalamus, basal ganglia, and cortex, demonstrating that reduced PiT2 expression alone can cause brain calcifications. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 2% |
| Unknown | 48 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 22% |
| Researcher | 8 | 16% |
| Student > Master | 6 | 12% |
| Other | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 14 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 16% |
| Biochemistry, Genetics and Molecular Biology | 7 | 14% |
| Medicine and Dentistry | 6 | 12% |
| Neuroscience | 5 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 16 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2013.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Journal of Molecular Neuroscience
#1,156
of 1,643 outputs
Outputs of similar age
#158,974
of 209,175 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#10
of 24 outputs
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So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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