| Title |
Focused ultrasound-induced blood–brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study
|
|---|---|
| Published in |
Journal of Translational Medicine, March 2015
|
| DOI | 10.1186/s12967-015-0451-y |
| Pubmed ID | |
| Authors |
Pin-Yuan Chen, Han-Yi Hsieh, Chiung-Yin Huang, Chun-Yen Lin, Kuo-Chen Wei, Hao-Li Liu |
| Abstract |
Interleukin-12 (IL-12) has long been considered to be effective in triggering an anticancer immune response, however, the dosage has been limited by potential systemic immunotoxicity. Since focused ultrasound (FUS) has been confirmed to temporally and locally open the blood-brain barrier (BBB), the purpose of this study was to elucidate the possibility of combining FUS-induced BBB opening with IL-12 delivery to enhance the anticancer immunological response for glioma treatment. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 1 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Unknown | 150 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 25% |
| Researcher | 23 | 15% |
| Student > Bachelor | 15 | 10% |
| Student > Master | 14 | 9% |
| Other | 7 | 5% |
| Other | 20 | 13% |
| Unknown | 36 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 20% |
| Engineering | 24 | 16% |
| Agricultural and Biological Sciences | 14 | 9% |
| Neuroscience | 12 | 8% |
| Chemistry | 7 | 5% |
| Other | 23 | 15% |
| Unknown | 42 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2022.
All research outputs
#2,828,207
of 25,604,262 outputs
Outputs from Journal of Translational Medicine
#496
of 4,684 outputs
Outputs of similar age
#36,857
of 292,541 outputs
Outputs of similar age from Journal of Translational Medicine
#6
of 91 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,684 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,541 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.