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Mendeley readers
Attention Score in Context
| Title |
Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody
|
|---|---|
| Published in |
Clinical Materials, February 2015
|
| DOI | 10.1016/j.biomaterials.2015.01.062 |
| Pubmed ID | |
| Authors |
Byungtae Hwang, Sang-Hyun Lee, Jang-Seong Kim, Ji Hyun Moon, In Cheul Jeung, Na Geum Lee, Jongjin Park, Hyo Jeong Hong, Young-Lai Cho, Haiyoung Jung, Young-Jun Park, Seon-Jin Lee, Hee Gu Lee, Won Kon Kim, Baek Soo Han, Kwang-Hee Bae, Sang J. Chung, Young-Guen Kwon, Sang Chul Lee, Sang Jick Kim, Jeong-Ki Min |
| Abstract |
Angiopoietin-1 (Ang1) and its endothelium-specific receptor, tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2), play critical roles in vascular development. Although the Ang1/Tie2 system has been considered a promising target for therapeutic neovascularization, several imitations of large-scale production have hampered the development of recombinant Ang1 for therapeutics. In this study, we produced a fully human agonistic antibody against Tie2, designated 1-4h, and tested the applicability of 1-4h as an alternative to native Ang1 in therapeutic angiogenesis. 1-4h significantly enhanced the phosphorylation of Tie2 in a dose- and time-dependent manner in human Tie2-expressing HEK293 cells and human umbilical vein endothelial cells. Moreover, 1-4h induced the activation of Tie2-mediated intracellular signaling such as AKT, eNOS, MAPK, and Focal Adhesion Kinase p125(FAK). In addition, 1-4h increased the chemotactic motility and capillary-like tube formation of endothelial cells in vitro and enhanced the survival of serum-deprived endothelial cells. Taken together, our data clearly suggest that a human Tie2 agonistic antibody is a potentially useful therapeutic approach for the treatment of several ischemic diseases including delayed-wound healing and ischemic heart and limb diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 3% |
| Unknown | 29 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 23% |
| Researcher | 5 | 17% |
| Other | 3 | 10% |
| Student > Bachelor | 2 | 7% |
| Student > Postgraduate | 2 | 7% |
| Other | 6 | 20% |
| Unknown | 5 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 20% |
| Medicine and Dentistry | 5 | 17% |
| Neuroscience | 2 | 7% |
| Engineering | 2 | 7% |
| Immunology and Microbiology | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 8 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2022.
All research outputs
#3,798,611
of 25,373,627 outputs
Outputs from Clinical Materials
#1,161
of 10,751 outputs
Outputs of similar age
#45,838
of 269,051 outputs
Outputs of similar age from Clinical Materials
#20
of 160 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,751 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,051 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.