Title |
A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome
|
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Published in |
European Journal of Clinical Microbiology & Infectious Diseases, September 2011
|
DOI | 10.1007/s10096-011-1411-y |
Pubmed ID | |
Authors |
A. Traverso, E. Repetto, S. Magnani, T. Meloni, M. Natrella, P. Marchisio, C. Giacomazzi, P. Bernardi, S. Gatti, M. A. Gomez Morales, E. Pozio |
Abstract |
We describe the greatest Italian human acute opisthorchiasis outbreak acquired from eating raw tenches. Out of 52 people with suspected opisthorchiasis, 45 resulted in being infected. The most frequent symptoms and laboratory findings were fever, abdominal pain and eosinophilia. Seven tri-phasic computed tomography (CT) scans were done, showing multiple hypodense nodules with hyper-enhancement in the arterial phase. All patients took one day of praziquantel 25 mg/kg TID without failures. Reported symptoms suggested a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome. It seems common to find hepatic imaging alterations during acute opisthorchiasis: CT scan could be the most suitable imaging examination. Even if stool test remains the diagnostic gold standard, we found earlier positivity with the serum antibody test. Without previous freezing, the consumption of raw freshwater fish should be avoided. |
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Geographical breakdown
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Australia | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Ecuador | 1 | 3% |
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Demographic breakdown
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Researcher | 7 | 19% |
Student > Bachelor | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Student > Master | 5 | 14% |
Student > Doctoral Student | 2 | 6% |
Other | 7 | 19% |
Unknown | 5 | 14% |
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Medicine and Dentistry | 4 | 11% |
Veterinary Science and Veterinary Medicine | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Nursing and Health Professions | 2 | 6% |
Other | 7 | 19% |
Unknown | 7 | 19% |