↓ Skip to main content

Autoinducer 2: a concentration‐dependent signal for mutualistic bacterial biofilm growth

Overview of attention for article published in Molecular Microbiology, May 2006
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
1 news outlet
patent
7 patents

Citations

dimensions_citation
309 Dimensions

Readers on

mendeley
258 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Autoinducer 2: a concentration‐dependent signal for mutualistic bacterial biofilm growth
Published in
Molecular Microbiology, May 2006
DOI 10.1111/j.1365-2958.2006.05202.x
Pubmed ID
Authors

Alexander H. Rickard, Robert J. Palmer, David S. Blehert, Shawn R. Campagna, Martin F. Semmelhack, Paul G. Egland, Bonnie L. Bassler, Paul E. Kolenbrander

Abstract

4,5-Dihydroxy-2,3-pentanedione (DPD), a product of the LuxS enzyme in the catabolism of S-ribosylhomocysteine, spontaneously cyclizes to form autoinducer 2 (AI-2). AI-2 is proposed to be a universal signal molecule mediating interspecies communication among bacteria. We show that mutualistic and abundant biofilm growth in flowing saliva of two human oral commensal bacteria, Actinomyces naeslundii T14V and Streptococcus oralis 34, is dependent upon production of AI-2 by S. oralis 34. A luxS mutant of S. oralis 34 was constructed which did not produce AI-2. Unlike wild-type dual-species biofilms, A. naeslundii T14V and an S. oralis 34 luxS mutant did not exhibit mutualism and generated only sparse biofilms which contained a 10-fold lower biomass of each species. Restoration of AI-2 levels by genetic or chemical (synthetic AI-2 in the form of DPD) complementation re-established the mutualistic growth and high biomass characteristic for the wild-type dual-species biofilm. Furthermore, an optimal concentration of DPD was determined, above and below which biofilm formation was suppressed. The optimal concentration was 100-fold lower than the detection limit of the currently accepted AI-2 assay. Thus, AI-2 acts as an interspecies signal and its concentration is critical for mutualism between two species of oral bacteria grown under conditions that are representative of the human oral cavity.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 258 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 3%
United Kingdom 2 <1%
Denmark 1 <1%
Italy 1 <1%
Greece 1 <1%
Spain 1 <1%
Unknown 245 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 77 30%
Researcher 37 14%
Student > Bachelor 35 14%
Student > Master 19 7%
Student > Doctoral Student 15 6%
Other 35 14%
Unknown 40 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 100 39%
Biochemistry, Genetics and Molecular Biology 23 9%
Immunology and Microbiology 21 8%
Medicine and Dentistry 20 8%
Chemistry 14 5%
Other 34 13%
Unknown 46 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2023.
All research outputs
#2,099,336
of 24,525,936 outputs
Outputs from Molecular Microbiology
#188
of 6,858 outputs
Outputs of similar age
#3,678
of 69,369 outputs
Outputs of similar age from Molecular Microbiology
#3
of 45 outputs
Altmetric has tracked 24,525,936 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,858 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.