| Title |
Mitochondrial Dysfunction and Oxidative Damage in Alzheimer's and Parkinson's Diseases and Coenzyme Q10 as a Potential Treatment
|
|---|---|
| Published in |
Journal of Bioenergetics and Biomembranes, August 2004
|
| DOI | 10.1023/b:jobb.0000041772.74810.92 |
| Pubmed ID | |
| Authors |
M. Flint Beal |
| Abstract |
There is substantial evidence that mitochondrial dysfunction and oxidative damage may play a key role in the pathogenesis of neurodegenerative disease. Evidence supporting this in both Alzheimer's and Parkinson's diseases is continuing to accumulate. This review discusses the increasing evidence for a role of both mitochondrial dysfunction and oxidative damage in contributing to beta-amyloid deposition in Alzheimer's disease. I also discuss the increasing evidence that Parkinson's disease is associated with abnormalities in the electron transport gene as well as oxidative damage. Lastly, I reviewed the potential efficacy of coenzyme Q as well as a number of other antioxidants in the treatment of both Parkinson's and Alzheimer's diseases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Germany | 1 | <1% |
| Portugal | 1 | <1% |
| Malaysia | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 122 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 18% |
| Student > Ph. D. Student | 22 | 17% |
| Researcher | 17 | 13% |
| Student > Master | 12 | 9% |
| Professor > Associate Professor | 7 | 5% |
| Other | 25 | 20% |
| Unknown | 22 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 25% |
| Medicine and Dentistry | 28 | 22% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Neuroscience | 10 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 11 | 9% |
| Unknown | 29 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2021.
All research outputs
#3,135,587
of 25,371,288 outputs
Outputs from Journal of Bioenergetics and Biomembranes
#20
of 491 outputs
Outputs of similar age
#5,210
of 61,344 outputs
Outputs of similar age from Journal of Bioenergetics and Biomembranes
#1
of 13 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 491 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 61,344 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.