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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae
|
|---|---|
| Published in |
Metabolic Engineering, March 2015
|
| DOI | 10.1016/j.ymben.2015.03.008 |
| Pubmed ID | |
| Authors |
T.C. Williams, N.J.H. Averesch, G. Winter, M.R. Plan, C.E. Vickers, L.K. Nielsen, J.O. Krömer |
| Abstract |
Some of the most productive metabolic engineering strategies involve genetic modifications that cause severe metabolic burden on the host cell. Growth-limiting genetic modifications can be more effective if they are 'switched on' after a population growth phase has been completed. To address this problem we have engineered dynamic regulation using a previously developed synthetic quorum sensing circuit in Saccharomyces cerevisiae. The circuit autonomously triggers gene expression at a high population density, and was linked with an RNA interference module to enable target gene silencing. As a demonstration the circuit was used to control flux through the shikimate pathway for the production of para-hydroxybenzoic acid (PHBA). Dynamic RNA repression allowed gene knock-downs which were identified by elementary flux mode analysis as highly productive but with low biomass formation to be implemented after a population growth phase, resulting in the highest published PHBA titer in yeast (1.1mM). |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 20% |
| United Kingdom | 1 | 10% |
| France | 1 | 10% |
| United States | 1 | 10% |
| Unknown | 5 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Scientists | 1 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 174 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Denmark | 1 | <1% |
| Singapore | 1 | <1% |
| Spain | 1 | <1% |
| China | 1 | <1% |
| Unknown | 168 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 25% |
| Researcher | 37 | 21% |
| Student > Master | 17 | 10% |
| Student > Bachelor | 16 | 9% |
| Student > Doctoral Student | 8 | 5% |
| Other | 15 | 9% |
| Unknown | 38 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 30% |
| Biochemistry, Genetics and Molecular Biology | 47 | 27% |
| Chemical Engineering | 9 | 5% |
| Engineering | 9 | 5% |
| Chemistry | 2 | 1% |
| Other | 5 | 3% |
| Unknown | 49 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2015.
All research outputs
#6,420,474
of 25,374,917 outputs
Outputs from Metabolic Engineering
#684
of 1,463 outputs
Outputs of similar age
#69,701
of 277,917 outputs
Outputs of similar age from Metabolic Engineering
#12
of 30 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,463 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,917 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.