| Title |
Quantitative profiling of endocannabinoids in lipoproteins by LC–MS/MS
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, March 2015
|
| DOI | 10.1007/s00216-015-8559-8 |
| Pubmed ID | |
| Authors |
Mesut Bilgin, Laura Bindila, Juergen Graessler, Andrej Shevchenko |
| Abstract |
Endocannabinoids belong to a diverse family of endogenous lipid bioregulators acting as physiological ligands of cannabinoid receptor type 1 and cannabinoid receptor type 2 in the central and peripheral nervous system. They are also present in nmol L(-1) concentrations in human blood plasma; however, their association with possible molecular carriers remains poorly characterized. Here we report on the quantification of 46 endogenous molecular species from five major classes of endocannabinoids and endocannabinoid-related compounds in three lipoprotein fractions of human blood plasma: VLDL, LDL, HDL, and in the plasma lipoprotein-free fraction. Although sizable quantities of endocannabinoid-related molecules are associated with lipoproteins, we identified the lipoprotein-free fraction as a major carrier of endocannabinoids in blood circulation with the exception of 2-acylglycerols, which are markedly abundant in VLDL. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 3 | 6% |
| United States | 2 | 4% |
| Unknown | 44 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 22% |
| Researcher | 8 | 16% |
| Student > Bachelor | 7 | 14% |
| Student > Master | 6 | 12% |
| Student > Doctoral Student | 3 | 6% |
| Other | 8 | 16% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 22% |
| Biochemistry, Genetics and Molecular Biology | 10 | 20% |
| Chemistry | 9 | 18% |
| Medicine and Dentistry | 5 | 10% |
| Neuroscience | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 10 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
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#22,834,739
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Outputs from Analytical & Bioanalytical Chemistry
#7,570
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Outputs of similar age
#251,001
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Outputs of similar age from Analytical & Bioanalytical Chemistry
#104
of 155 outputs
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