| Title |
Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients
|
|---|---|
| Published in |
Journal of Endocrinological Investigation, October 2017
|
| DOI | 10.1007/s40618-017-0782-z |
| Pubmed ID | |
| Authors |
A. D. Genazzani, K. Shefer, D. Della Casa, A. Prati, A. Napolitano, A. Manzo, G. Despini, T. Simoncini |
| Abstract |
To evaluate the efficacy of alpha-lipoic acid (ALA) administration on hormonal and metabolic parameters of obese PCOS patients. A group of 32 obese PCOS patients were selected after informed consent. 20 patients referred to have first grade relatives with diabetes type I or II. Hormonal and metabolic parameters as well as OGTT were evaluated before and after 12 weeks of ALA integrative administration (400 mg per os every day). ALA administration significantly decreased insulin, glucose, BMI and HOMA index. Hyperinsulinemia and insulin response to OGTT decreased both as maximal response (Δmax) and as AUC. PCOS with diabetes relatives showed the decrease also of triglyceride and GOT. Interestingly in all PCOS no changes occurred on all hormonal parameters involved in reproduction such as LH, FSH, and androstenedione. ALA integrative administration at a low dosage as 400 mg daily improved the metabolic impairment of all PCOS patients especially in those PCOS with familiar diabetes who have a higher grade of risk of NAFLD and predisposition to diabetes. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 25% |
| United Kingdom | 2 | 13% |
| India | 1 | 6% |
| Indonesia | 1 | 6% |
| New Zealand | 1 | 6% |
| Unknown | 7 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 81% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 11% |
| Student > Bachelor | 8 | 11% |
| Student > Ph. D. Student | 6 | 8% |
| Student > Postgraduate | 6 | 8% |
| Student > Master | 4 | 5% |
| Other | 12 | 16% |
| Unknown | 30 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Nursing and Health Professions | 3 | 4% |
| Unspecified | 2 | 3% |
| Other | 9 | 12% |
| Unknown | 32 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2023.
All research outputs
#1,196,383
of 25,382,440 outputs
Outputs from Journal of Endocrinological Investigation
#45
of 1,622 outputs
Outputs of similar age
#24,723
of 340,266 outputs
Outputs of similar age from Journal of Endocrinological Investigation
#1
of 20 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,622 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.