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X Demographics
Mendeley readers
Attention Score in Context
| Title |
New insights into Lyme disease
|
|---|---|
| Published in |
Redox Biology, March 2015
|
| DOI | 10.1016/j.redox.2015.03.002 |
| Pubmed ID | |
| Authors |
Brandon N. Peacock, Teshome B. Gherezghiher, Jennifer D. Hilario, Gottfried H. Kellermann |
| Abstract |
Lyme borreliosis is transmitted through the bite of a tick that is infected by the bacterial spirochete Borrelia burgdorferi. Clinical manifestation of the disease can lead to heart conditions, neurological disorders, and inflammatory disorders. Oxidative stress has been implicated in the pathogenesis of many human diseases. The aim of this study was to investigate the mechanisms of oxidative stress and intracellular communication in Lyme borreliosis patients. Mitochondrial superoxide and cytosolic ionized calcium was measured in peripheral blood mononuclear cells (PBMCs) of Lyme borreliosis patients and healthy controls. Mitochondrial superoxide levels were significantly higher (p<0.0001) in Lyme borreliosis patients (n=32) as compared to healthy controls (n=30). Significantly low (p<0.0001) levels of cytosolic ionized calcium were also observed in Lyme borreliosis patients (n=11) when compared to healthy controls (n=11). These results indicate that there is an imbalance of reactive oxygen species and cytosolic calcium in Lyme borreliosis patients. The results further suggest that oxidative stress and interrupted intracellular communication may ultimately contribute to a condition of mitochondrial dysfunction in the immune cells of Lyme borreliosis patients. |
X Demographics
The data shown below were collected from the profiles of 59 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 24 | 41% |
| Canada | 2 | 3% |
| Georgia | 2 | 3% |
| Australia | 1 | 2% |
| United Kingdom | 1 | 2% |
| Unknown | 29 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 49 | 83% |
| Practitioners (doctors, other healthcare professionals) | 4 | 7% |
| Scientists | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 3 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| United States | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 56 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 17% |
| Researcher | 9 | 15% |
| Other | 7 | 12% |
| Student > Doctoral Student | 6 | 10% |
| Professor | 4 | 7% |
| Other | 16 | 27% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Agricultural and Biological Sciences | 7 | 12% |
| Immunology and Microbiology | 5 | 8% |
| Social Sciences | 3 | 5% |
| Other | 17 | 28% |
| Unknown | 10 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2024.
All research outputs
#620,512
of 25,651,057 outputs
Outputs from Redox Biology
#50
of 2,057 outputs
Outputs of similar age
#7,525
of 278,628 outputs
Outputs of similar age from Redox Biology
#1
of 18 outputs
Altmetric has tracked 25,651,057 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,057 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,628 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.