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Urinary Iodine Excretion and Serum Thyroid Function in Adults After Iodinated Contrast Administration

Overview of attention for article published in Thyroid, March 2015
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Title
Urinary Iodine Excretion and Serum Thyroid Function in Adults After Iodinated Contrast Administration
Published in
Thyroid, March 2015
DOI 10.1089/thy.2015.0024
Pubmed ID
Authors

Sun Y. Lee, Donny L.F. Chang, Xuemei He, Elizabeth N. Pearce, Lewis E. Braverman, Angela M. Leung

Abstract

Background Iodinated contrast media (ICM) is a source of excess iodine which may induce thyroid dysfunction. We conducted a prospective cohort study to assess the effects of ICM on urinary iodine clearance and serum thyroid function tests (TFTs) in adults. Methods In this prospective cohort study of 54 adults undergoing elective CT scans at an academic medical center, serial urinary iodine concentrations (UIC) and serum TFTs were obtained until UIC normalized following ICM administration. Thyroid volume/nodularity were assessed by ultrasound. Associations between covariates and peak UIC, duration for UIC to peak and normalize, and thyroid dysfunction risk were assessed. Results Mean±SD iodine administered was 34.6±6.0g. Baseline median(range) UIC was 105.1(17.0-866.1)µg/L and serum thyroid-stimulating hormone (TSH) concentration was 1.26(0.5-11.2)mIU/L. Mean±SD time to achieve peak UIC [median(range): 3,519(233-157,500)µg/L] and normalized UIC were 1.1±0.5 and 5.2±4.0 weeks, respectively. Four subjects had elevated baseline TSH and one had missing baseline TSH values; of the remaining 49 subjects, 11(22%) developed an abnormal TSH within 1-4 weeks (six elevated and five decreased). Administered iodine amount correlated with peak UIC following ICM administration (p<0.001). Increasing age and administered iodine amount predicted peak UIC (p=0.024 and p<0.001, respectively). Age, gender, race, smoking status, family history of thyroid disease, personal or family history of thyroid autoimmunity, thyroid volume, presence of thyroid nodules ≥1cm, iodine dose, baseline UIC, and baseline TFTs were not predictive of durations to achieve peak or normalized UIC. Conclusion Peak UIC occurred at 1.1 weeks and normalized by 5.2 weeks following ICM administration for outpatient CT scans. Because thyroid dysfunction developed in 22% individuals following a single ICM dose, monitoring of thyroid function should be considered in at-risk patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
United States 1 2%
Unknown 39 95%

Demographic breakdown

Readers by professional status Count As %
Other 6 15%
Researcher 6 15%
Student > Ph. D. Student 5 12%
Student > Doctoral Student 4 10%
Professor 3 7%
Other 7 17%
Unknown 10 24%
Readers by discipline Count As %
Medicine and Dentistry 18 44%
Biochemistry, Genetics and Molecular Biology 4 10%
Agricultural and Biological Sciences 2 5%
Nursing and Health Professions 1 2%
Neuroscience 1 2%
Other 2 5%
Unknown 13 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2015.
All research outputs
#17,286,645
of 25,377,790 outputs
Outputs from Thyroid
#1,573
of 2,211 outputs
Outputs of similar age
#169,547
of 278,103 outputs
Outputs of similar age from Thyroid
#16
of 25 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,211 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,103 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.