Title |
An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence
|
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Published in |
Gastric Cancer, March 2015
|
DOI | 10.1007/s10120-015-0487-y |
Pubmed ID | |
Authors |
Victor D. Martinez, Katey S. S. Enfield, David A. Rowbotham, Wan L. Lam |
Abstract |
The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 22% |
Student > Master | 7 | 19% |
Researcher | 5 | 14% |
Student > Bachelor | 4 | 11% |
Student > Postgraduate | 3 | 8% |
Other | 4 | 11% |
Unknown | 6 | 16% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 35% |
Agricultural and Biological Sciences | 8 | 22% |
Medicine and Dentistry | 3 | 8% |
Unspecified | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 8% |
Unknown | 8 | 22% |