Diffuse and focal bone marrow infiltration patterns detected by magnetic resonance imaging have been shown to be of prognostic significance in all stages of monoclonal plasma cell disorders and have therefore been incorporated into the definition of the disease. The aim of this retrospective analysis was to develop a rapidly evaluable prognostic scoring system, incorporating the most significant information acquired from magnetic resonance imaging. Therefore, the impact on progression-free and overall survival in 161 transplant-eligible myeloma patients was evaluated. Moderate/severe diffuse infiltration showed a negative prognostic impact on progression-free (p<0.001) and overall survival (p=0.003) compared to salt and pepper/minimal diffuse infiltration. A number of >25 focal lesions on whole-body or >7 on axial magnetic resonance imaging, were associated with an adverse prognosis (progression-free survival: p=0.001/0.003 and overall survival: p=0.04/0.02). A magnetic resonance imaging-based prognostic scoring system, combining grouped diffuse and focal infiltration patterns, was formulated and is applicable to whole-body as well as axial magnetic resonance imaging. The score identified high-risk patients with a median progression-free and overall survival of 23.4 and 55.9 months, respectively (whole-body-based). Multivariate analyses demonstrated that the magnetic resonance imaging-based prognostic score stage III (high-risk) and adverse cytogenetics remain as independent prognostic factors for both, progression-free and overall survival (whole-body-based, progression-free survival: hazard ratio=3.65, p<0.001; overall survival: hazard ratio=5.19, p=0.005). In conclusion, we suggest a magnetic resonance imaging-based prognostic scoring system which is a robust easy to assess and interpret parameter summarizing significant magnetic resonance imaging findings in transplant-eligible multiple myeloma patients.
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2016.
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#8,914,340
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#19
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Altmetric has tracked 29,606,669 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
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