| Title |
JAM-related proteins in mucosal homeostasis and inflammation
|
|---|---|
| Published in |
Seminars in Immunopathology, March 2014
|
| DOI | 10.1007/s00281-014-0421-0 |
| Pubmed ID | |
| Authors |
Anny-Claude Luissint, Asma Nusrat, Charles A. Parkos |
| Abstract |
Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body against external noxious substances and pathogens. At a molecular level, the mucosal barrier is regulated by tight junctions (TJs) that seal the paracellular space between adjacent epithelial cells. Transmembrane proteins within TJs include junctional adhesion molecules (JAMs) that belong to the cortical thymocyte marker for Xenopus family of proteins. JAM family encompasses three classical members (JAM-A, JAM-B, and JAM-C) and related molecules including JAM4, JAM-like protein, Coxsackie and adenovirus receptor (CAR), CAR-like membrane protein and endothelial cell-selective adhesion molecule. JAMs have multiple functions that include regulation of endothelial and epithelial paracellular permeability, leukocyte recruitment during inflammation, angiogenesis, cell migration, and proliferation. In this review, we summarize the current knowledge regarding the roles of the JAM family members in the regulation of mucosal homeostasis and leukocyte trafficking with a particular emphasis on barrier function and its perturbation during pathological inflammation. |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Netherlands | 1 | 1% |
| France | 1 | 1% |
| United Kingdom | 1 | 1% |
| Venezuela, Bolivarian Republic of | 1 | 1% |
| Unknown | 72 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Student > Master | 13 | 17% |
| Researcher | 8 | 10% |
| Student > Bachelor | 8 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 10 | 13% |
| Unknown | 15 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 30% |
| Biochemistry, Genetics and Molecular Biology | 14 | 18% |
| Immunology and Microbiology | 8 | 10% |
| Chemistry | 2 | 3% |
| Nursing and Health Professions | 1 | 1% |
| Other | 8 | 10% |
| Unknown | 21 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2014.
All research outputs
#20,265,771
of 22,796,179 outputs
Outputs from Seminars in Immunopathology
#474
of 546 outputs
Outputs of similar age
#192,222
of 224,658 outputs
Outputs of similar age from Seminars in Immunopathology
#9
of 11 outputs
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