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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Improved Biofilm Antimicrobial Activity of Polyethylene Glycol Conjugated Tobramycin Compared to Tobramycin in Pseudomonas aeruginosa Biofilms
|
|---|---|
| Published in |
Molecular Pharmaceutics, April 2015
|
| DOI | 10.1021/mp500846u |
| Pubmed ID | |
| Authors |
Ju Du, H M H N Bandara, Ping Du, Hui Huang, Khang Hoang, Dang Nguyen, Sri Vasudha Mogarala, Hugh D C Smyth |
| Abstract |
The objective of this study was to develop a functionally enhanced antibiotic that would improve the therapeutic activity against bacterial biofilms. Tobramycin was chemically conjugated with polyethylene glycol (PEG) via site specific conjugation to form PEGylated-tobramycin (Tob-PEG). The antibacterial efficacy of Tob-PEG, as compared to tobramycin, was assessed on the planktonic phase and biofilms phase of Pseudomonas aeruginosa. The minimum inhibitory concentration (MIC80) of Tob-PEG was higher (13.9 µmol/L) than that of tobramycin (1.4 µmol/L) in the planktonic phases. In contrast, the Tob-PEG was approximately 3.2 fold more effective in eliminating bacterial biofilms than tobramycin. Specifically, Tob-PEG had MIC80 lower than those exhibited by tobramycin (27.8 µmol/L vs 89.8 µmol/L). Confocal laser scanning microscope and scanning electron microscope findings further confirmed these data. Thus, modification of antimicrobial as by PEGylation appears to be a promising approach for overcoming the bacterial resistance in the established biofilms of Pseudomonas aeruginosa. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 22% |
| United Kingdom | 1 | 11% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 65 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 21% |
| Researcher | 12 | 18% |
| Student > Bachelor | 8 | 12% |
| Student > Doctoral Student | 6 | 9% |
| Student > Master | 5 | 8% |
| Other | 8 | 12% |
| Unknown | 13 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 14 | 21% |
| Agricultural and Biological Sciences | 9 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Medicine and Dentistry | 3 | 5% |
| Other | 15 | 23% |
| Unknown | 15 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2021.
All research outputs
#4,299,028
of 23,628,742 outputs
Outputs from Molecular Pharmaceutics
#473
of 4,273 outputs
Outputs of similar age
#52,870
of 264,731 outputs
Outputs of similar age from Molecular Pharmaceutics
#8
of 54 outputs
Altmetric has tracked 23,628,742 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,273 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,731 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.