| Title |
Differentiation Potential of Human Chorion-Derived Mesenchymal Stem Cells into Motor Neuron-Like Cells in Two- and Three-Dimensional Culture Systems
|
|---|---|
| Published in |
Molecular Neurobiology, March 2015
|
| DOI | 10.1007/s12035-015-9129-y |
| Pubmed ID | |
| Authors |
Faezeh Faghihi, Esmaeil Mirzaei, Jafar Ai, Abolfazl Lotfi, Forough Azam Sayahpour, Somayeh Ebrahimi Barough, Mohammad Taghi Joghataei |
| Abstract |
Many people worldwide suffer from motor neuron-related disorders such as amyotrophic lateral sclerosis and spinal cord injuries. Recently, several attempts have been made to recruit stem cells to modulate disease progression in ALS and also regenerate spinal cord injuries. Chorion-derived mesenchymal stem cells (C-MSCs), used to be discarded as postpartum medically waste product, currently represent a class of cells with self renewal property and immunomodulatory capacity. These cells are able to differentiate into mesodermal and nonmesodermal lineages such as neural cells. On the other hand, gelatin, as a simply denatured collagen, is a suitable substrate for cell adhesion and differentiation. It has been shown that electrospinning of scaffolds into fibrous structure better resembles the physiological microenvironment in comparison with two-dimensional (2D) culture system. Since there is no report on potential of human chorion-derived MSCs to differentiate into motor neuron cells in two- and three-dimensional (3D) culture systems, we set out to determine the effect of retinoic acid (RA) and sonic hedgehog (Shh) on differentiation of human C-MSCs into motor neuron-like cells cultured on tissue culture plates (2D) and electrospun nanofibrous gelatin scaffold (3D). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Australia | 1 | 2% |
| Egypt | 1 | 2% |
| Unknown | 58 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 23% |
| Student > Master | 12 | 20% |
| Student > Bachelor | 5 | 8% |
| Researcher | 4 | 7% |
| Student > Postgraduate | 4 | 7% |
| Other | 14 | 23% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 18% |
| Agricultural and Biological Sciences | 11 | 18% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Engineering | 7 | 11% |
| Neuroscience | 4 | 7% |
| Other | 10 | 16% |
| Unknown | 9 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2015.
All research outputs
#20,265,771
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Outputs from Molecular Neurobiology
#2,784
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Outputs of similar age
#222,605
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Outputs of similar age from Molecular Neurobiology
#40
of 52 outputs
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