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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nicotine normalizes cortico-striatal connectivity in non-smoking individuals with major depressive disorder
|
|---|---|
| Published in |
Neuropsychopharmacology, April 2018
|
| DOI | 10.1038/s41386-018-0069-x |
| Pubmed ID | |
| Authors |
Amy C. Janes, Maya Zegel, Kyoko Ohashi, Jennifer Betts, Elena Molokotos, David Olson, Lauren Moran, Diego A. Pizzagalli |
| Abstract |
Nicotine dependence and major depressive disorder (MDD) are highly comorbid, yet causal links between these prevalent disorders are unclear. One possible mechanism is that nicotine ameliorates MDD-related neurobiological dysfunction in specific networks. For instance, cortico-striatal circuitry is enhanced by nicotine, and such paths are disrupted in individuals with MDD. Specifically, MDD has been associated with reduced connectivity between the nucleus accumbens (NAc) and rostral anterior cingulate cortex (rACC) but enhanced connectivity between the dorsal striatum (DS) and dorsolateral prefrontal cortex (DLPFC). Determining whether nicotine normalizes these circuits in non-smokers with MDD may elucidate mechanisms underlying links between disorders. This was tested by administering placebo and a 2-mg dose of nicotine to unmedicated non-smokers with and without MDD prior to collecting resting-state functional magnetic imaging data using a cross-over design. On placebo, individuals with MDD showed significantly reduced NAc-rACC and a trend for enhanced DS-DLPFC functional connectivity relative to healthy controls. In MDD, acute nicotine administration normalized both pathways to the level of healthy controls, while having no impact on healthy controls. Nicotine's effects on NAc-rACC connectivity was influenced by anhedonia, consistent with the role of this network in reward and nicotine's ability to enhance reward deficiencies in MDD. These results indicate that nicotine normalizes dysfunctional cortico-striatal communication in unmedicated non-smokers with MDD. Nicotine's influence on these circuitries highlights a possible mechanism whereby individuals with MDD are more vulnerable to develop nicotine dependence. Findings suggest that nicotinic agents may have therapeutic effects on disrupted cortico-striatal connectivity. |
X Demographics
The data shown below were collected from the profiles of 65 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 29% |
| Australia | 5 | 8% |
| Mexico | 2 | 3% |
| Canada | 2 | 3% |
| Germany | 2 | 3% |
| Myanmar | 1 | 2% |
| Central African Republic | 1 | 2% |
| Nigeria | 1 | 2% |
| Guinea | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 30 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 61 | 94% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
| Scientists | 1 | 2% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 11% |
| Researcher | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Student > Master | 6 | 10% |
| Professor > Associate Professor | 4 | 7% |
| Other | 10 | 16% |
| Unknown | 21 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 15% |
| Psychology | 7 | 11% |
| Medicine and Dentistry | 7 | 11% |
| Nursing and Health Professions | 6 | 10% |
| Social Sciences | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 28 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2024.
All research outputs
#1,065,564
of 25,756,531 outputs
Outputs from Neuropsychopharmacology
#461
of 5,214 outputs
Outputs of similar age
#23,143
of 341,993 outputs
Outputs of similar age from Neuropsychopharmacology
#13
of 77 outputs
Altmetric has tracked 25,756,531 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,214 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,993 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.