Title |
The bacterial replisome has factory-like localization
|
---|---|
Published in |
Current Genetics, April 2018
|
DOI | 10.1007/s00294-018-0830-z |
Pubmed ID | |
Authors |
Sarah M. Mangiameli, Julie A. Cass, Houra Merrikh, Paul A. Wiggins |
Abstract |
DNA replication is essential to cellular proliferation. The cellular-scale organization of the replication machinery (replisome) and the replicating chromosome has remained controversial. Two competing models describe the replication process: In the track model, the replisomes translocate along the DNA like a train on a track. Alternately, in the factory model, the replisomes form a stationary complex through which the DNA is pulled. We summarize the evidence for each model and discuss a number of confounding aspects that complicate interpretation of the observations. We advocate a factory-like model for bacterial replication where the replisomes form a relatively stationary and weakly associated complex that can transiently separate. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 36% |
Netherlands | 2 | 18% |
Chile | 1 | 9% |
Switzerland | 1 | 9% |
Australia | 1 | 9% |
Unknown | 2 | 18% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 10 | 91% |
Members of the public | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 29% |
Researcher | 4 | 13% |
Student > Bachelor | 4 | 13% |
Student > Postgraduate | 3 | 10% |
Student > Master | 2 | 6% |
Other | 3 | 10% |
Unknown | 6 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 32% |
Agricultural and Biological Sciences | 7 | 23% |
Physics and Astronomy | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Chemistry | 2 | 6% |
Other | 2 | 6% |
Unknown | 6 | 19% |