| Title |
Much more than a leak: structure and function of K2P-channels
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, March 2015
|
| DOI | 10.1007/s00424-015-1703-7 |
| Pubmed ID | |
| Authors |
Vijay Renigunta, Günter Schlichthörl, Jürgen Daut |
| Abstract |
Over the last decade, we have seen an enormous increase in the number of experimental studies on two-pore-domain potassium channels (K2P-channels). The collection of reviews and original articles compiled for this special issue of Pflügers Archiv aims to give an up-to-date summary of what is known about the physiology and pathophysiology of K2P-channels. This introductory overview briefly describes the structure of K2P-channels and their function in different organs. Its main aim is to provide some background information for the 19 reviews and original articles of this special issue of Pflügers Archiv. It is not intended to be a comprehensive review; instead, this introductory overview focuses on some unresolved questions and controversial issues, such as: Do K2P-channels display voltage-dependent gating? Do K2P-channels contribute to the generation of action potentials? What is the functional role of alternative translation initiation? Do K2P-channels have one or two or more gates? We come to the conclusion that we are just beginning to understand the extremely complex regulation of these fascinating channels, which are often inadequately described as 'leak channels'. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 126 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 24% |
| Researcher | 18 | 14% |
| Student > Master | 18 | 14% |
| Student > Doctoral Student | 13 | 10% |
| Student > Bachelor | 7 | 5% |
| Other | 16 | 12% |
| Unknown | 28 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 27% |
| Biochemistry, Genetics and Molecular Biology | 20 | 15% |
| Neuroscience | 15 | 11% |
| Medicine and Dentistry | 15 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Other | 13 | 10% |
| Unknown | 26 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2015.
All research outputs
#19,221,261
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,557
of 1,973 outputs
Outputs of similar age
#194,591
of 264,288 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#7
of 9 outputs
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