| Title |
Isolation of a new cell population in the glioblastoma microenvironment
|
|---|---|
| Published in |
Journal of Neuro-Oncology, September 2011
|
| DOI | 10.1007/s11060-011-0701-7 |
| Pubmed ID | |
| Authors |
Anne Clavreul, Amandine Etcheverry, Agnès Chassevent, Véronique Quillien, Tony Avril, Marie-Lise Jourdan, Sophie Michalak, Patrick François, Jean-Luc Carré, Jean Mosser, The Grand Ouest Glioma Project Network, Philippe Menei |
| Abstract |
Glioblastoma (GB) is a highly infiltrative tumor recurring in 90% of cases within a few centimeters of the resection cavity, even in cases of complete tumor resection and adjuvant chemo/radiotherapy. This observation highlights the importance of understanding this special zone of brain tissue surrounding the tumor. It is becoming clear that the nonneoplastic stromal compartment of most solid cancers plays an active role in tumor proliferation, invasion, and metastasis. Very little information, other than that concerning angiogenesis and immune cells, has been collected for stromal cells from GB. As part of a translational research program, we have isolated a new stromal cell population surrounding GB by computer-guided stereotaxic biopsies and primary culture. We named these cells GB-associated stromal cells (GASCs). GASCs are diploid, do not display the genomic alterations typical of GB cells, and have phenotypic and functional properties in common with the cancer-associated fibroblasts (CAFs) described in the stroma of carcinomas. In particular, GASCs express markers associated with CAFs such as fibroblast surface protein, alpha-smooth muscle actin (α-SMA), and platelet-derived growth factor receptor-beta (PDGFRβ). Furthermore, GASCs have a molecular expression profile different from that of control stromal cells derived from non-GB peripheral brain tissues. GASCs were also found to have tumor-promoting effects on glioma cells in vitro and in vivo. The isolation of GASCs in a tumor of neuroepithelial origin was unexpected, and further studies are required to determine their potential as a target for antiglioma treatment. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| United Kingdom | 1 | 1% |
| Belgium | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 64 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 22% |
| Researcher | 14 | 20% |
| Student > Bachelor | 7 | 10% |
| Student > Postgraduate | 4 | 6% |
| Student > Master | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 26% |
| Biochemistry, Genetics and Molecular Biology | 12 | 17% |
| Agricultural and Biological Sciences | 11 | 16% |
| Neuroscience | 3 | 4% |
| Immunology and Microbiology | 2 | 3% |
| Other | 8 | 12% |
| Unknown | 15 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2018.
All research outputs
#7,408,141
of 22,651,245 outputs
Outputs from Journal of Neuro-Oncology
#1,033
of 2,954 outputs
Outputs of similar age
#44,461
of 130,244 outputs
Outputs of similar age from Journal of Neuro-Oncology
#8
of 27 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,954 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,244 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.