| Title |
Silk fibroin-based woven endovascular prosthesis with heparin surface modification
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, April 2018
|
| DOI | 10.1007/s10856-018-6055-3 |
| Pubmed ID | |
| Authors |
Zekun Liu, Gang Li, Zhaozhu Zheng, Yuling Li, Yifan Han, David L. Kaplan, Xiaoqin Wang |
| Abstract |
A novel seamless silk fibroin-based endovascular prosthesis (SFEPs) with bifurcated woven structure and anticoagulant function for the improvement of patency is described. The SFEPs were prepared from silk fibroin (SF) and polyester filaments using an installed weaving machine. The production processing parameters were optimized using orthogonal design methods. The inner surface of SFEPs was modified with polyethylenimine (PEI) and EDC/NHS-activated low-molecular-weight heparin (LMWH) to enhance anticoagulant function. The surface morphology and mechanical properties of the SFEPs were evaluated according to standard protocols. The thickness of modified SFEPs was lower than 0.085 ± 0.004 mm and water permeability was lower than 5.19 ± 0.30 mL/(cm2 × min). The results of mechanical properties showed that the diametral tensile strength and burst strength reached 61.6 ± 1.8 and 23.7 ± 2.2 MPa, respectively. Automatic coagulometer and energy-dispersive X-ray (EDX) confirmed LMWH immobilization on the surface of the SFEPs and the blood compatibility was improved with the heparin modification with PEI polymerization. In conclusion, the new prosthesis has potential applications in the blood vessel repairs where minimal thickness but superior mechanical strength and biocompatibility are important. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 26% |
| Student > Master | 6 | 22% |
| Other | 4 | 15% |
| Student > Bachelor | 2 | 7% |
| Researcher | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Materials Science | 4 | 15% |
| Agricultural and Biological Sciences | 2 | 7% |
| Engineering | 2 | 7% |
| Chemistry | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 11 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2023.
All research outputs
#7,651,370
of 24,580,204 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#318
of 1,442 outputs
Outputs of similar age
#125,322
of 333,739 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#3
of 14 outputs
Altmetric has tracked 24,580,204 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,442 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,739 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.