| Title |
Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up
|
|---|---|
| Published in |
Acta Diabetologica, January 2012
|
| DOI | 10.1007/s00592-011-0361-2 |
| Pubmed ID | |
| Authors |
Gianluca Perseghin, Giliola Calori, Guido Lattuada, Francesca Ragogna, Erika Dugnani, Maria Paola Garancini, Paolo Crosignani, Marco Villa, Emanuele Bosi, Giacomo Ruotolo, Lorenzo Piemonti |
| Abstract |
Type 2 diabetes is associated with risk of cancer. Hyperinsulinemia and insulin resistance may be the link with cancer, but whether this is independent of the diabetes status, obesity/visceral obesity and metabolic syndrome is uncertain and the present study wanted to address this issue. Fifteen-year all-cause, CVD and cancer mortality data were obtained through the Regional Health Registry in 2,011 out of 2,074 Caucasian middle-aged individuals of the Cremona Study, a population study on the prevalence of diabetes mellitus in Italy in which anthropometric and metabolic characteristics were collected. During the 15-year observation period, 495 deaths were registered: 221 CVD related and 180 cancer related. Age and sex were independently associated with all-cause, cancer and CVD mortality rates. Age- and sex-adjusted analysis showed that HOMA-IR, cigarette smoking and diabetes were independently associated with all-cause mortality; HOMA-IR, systolic blood pressure and fibrinogen were independently associated with CVD mortality; HOMA-IR and smoking habit were independently associated with cancer mortality. Individuals in the highest quintile of serum insulin had a 62% higher risk of cancer mortality (HR = 1.62 95% CI: 1.19-2.20; P < 0.0022) and 161% higher risk of gastrointestinal cancer mortality (HR = 2.61 95% CI: 1.73-3.94; P < 0.0001). Age- and sex-adjusted analysis showed that hyperinsulinemia/insulin resistance is associated with cancer mortality independently of diabetes, obesity/visceral obesity and the metabolic syndrome. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 18% |
| United Kingdom | 3 | 8% |
| Germany | 1 | 3% |
| Cameroon | 1 | 3% |
| India | 1 | 3% |
| Australia | 1 | 3% |
| Ireland | 1 | 3% |
| Unknown | 23 | 61% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 71% |
| Practitioners (doctors, other healthcare professionals) | 9 | 24% |
| Scientists | 1 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 73 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 19% |
| Student > Ph. D. Student | 14 | 19% |
| Other | 8 | 11% |
| Student > Master | 6 | 8% |
| Professor | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 19 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 35% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Nursing and Health Professions | 5 | 7% |
| Agricultural and Biological Sciences | 4 | 5% |
| Physics and Astronomy | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 21 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2020.
All research outputs
#1,537,401
of 25,579,912 outputs
Outputs from Acta Diabetologica
#37
of 1,037 outputs
Outputs of similar age
#9,951
of 251,095 outputs
Outputs of similar age from Acta Diabetologica
#1
of 6 outputs
Altmetric has tracked 25,579,912 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,037 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 96% of its peers.
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