| Title |
Structure and function insights into the NuRD chromatin remodeling complex
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2015
|
| DOI | 10.1007/s00018-015-1880-8 |
| Pubmed ID | |
| Authors |
Morgan P. Torchy, Ali Hamiche, Bruno P. Klaholz |
| Abstract |
Transcription regulation through chromatin compaction and decompaction is regulated through various chromatin-remodeling complexes such as nucleosome remodeling and histone deacetylation (NuRD) complex. NuRD is a 1 MDa multi-subunit protein complex which comprises many different subunits, among which histone deacetylases HDAC1/2, ATP-dependent remodeling enzymes CHD3/4, histone chaperones RbAp46/48, CpG-binding proteins MBD2/3, the GATAD2a (p66α) and/or GATAD2b (p66β) and specific DNA-binding proteins MTA1/2/3. Here, we review the currently known crystal and NMR structures of these subunits, the functional data and their relevance for biomedical research considering the implication of NuRD subunits in cancer and various other diseases. The complexity of this macromolecular assembly, and its poorly understood mode of interaction with the nucleosome, the repeating unit of chromatin, illustrate that this complex is a major challenge for structure-function relationship studies which will be tackled best by an integrated biology approach. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 289 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| Denmark | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 282 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 24% |
| Student > Bachelor | 47 | 16% |
| Student > Master | 40 | 14% |
| Researcher | 32 | 11% |
| Student > Doctoral Student | 14 | 5% |
| Other | 41 | 14% |
| Unknown | 46 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 130 | 45% |
| Agricultural and Biological Sciences | 75 | 26% |
| Medicine and Dentistry | 10 | 3% |
| Chemistry | 8 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 1% |
| Other | 10 | 3% |
| Unknown | 52 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2015.
All research outputs
#15,360,722
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,974
of 4,151 outputs
Outputs of similar age
#148,749
of 264,250 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#31
of 56 outputs
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