| Title |
Identification of a Sorbicillinoid-Producing Aspergillus Strain with Antimicrobial Activity Against Staphylococcus aureus: a New Polyextremophilic Marine Fungus from Barents Sea
|
|---|---|
| Published in |
Marine Biotechnology, April 2018
|
| DOI | 10.1007/s10126-018-9821-9 |
| Pubmed ID | |
| Authors |
Paulina Corral, Fortunato Palma Esposito, Pietro Tedesco, Angela Falco, Emiliana Tortorella, Luciana Tartaglione, Carmen Festa, Maria Valeria D’Auria, Giorgio Gnavi, Giovanna Cristina Varese, Donatella de Pascale |
| Abstract |
The exploration of poorly studied areas of Earth can highly increase the possibility to discover novel bioactive compounds. In this study, the cultivable fraction of fungi and bacteria from Barents Sea sediments has been studied to mine new bioactive molecules with antibacterial activity against a panel of human pathogens. We isolated diverse strains of psychrophilic and halophilic bacteria and fungi from a collection of nine samples from sea sediment. Following a full bioassay-guided approach, we isolated a new promising polyextremophilic marine fungus strain 8Na, identified as Aspergillus protuberus MUT 3638, possessing the potential to produce antimicrobial agents. This fungus, isolated from cold seawater, was able to grow in a wide range of salinity, pH and temperatures. The growth conditions were optimised and scaled to fermentation, and its produced extract was subjected to chemical analysis. The active component was identified as bisvertinolone, a member of sorbicillonoid family that was found to display significant activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 30 μg/mL. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 19% |
| Student > Bachelor | 4 | 11% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Master | 4 | 11% |
| Professor | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 14 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 6 | 16% |
| Agricultural and Biological Sciences | 6 | 16% |
| Biochemistry, Genetics and Molecular Biology | 5 | 14% |
| Chemistry | 3 | 8% |
| Environmental Science | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 14 | 38% |