| Title |
RETRACTED ARTICLE: Curcumin inhibits lung cancer progression and metastasis through induction of FOXO1
|
|---|---|
| Published in |
Tumor Biology, July 2013
|
| DOI | 10.1007/s13277-013-1013-7 |
| Pubmed ID | |
| Authors |
Zhen-Cai Li, Li-Ming Zhang, Hai-Bin Wang, Jun-Xun Ma, Jun-Zhong Sun |
| Abstract |
Recent population studies provide clues that the use of curcumin may be associated with reduced incidence and improved prognosis of certain cancers. In the present study, we demonstrated that curcumin acted as a growth inhibitor for lung cancer cells. Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. These findings provide evidence for a mechanism that may contribute to the antineoplastic effects of curcumin and justify further work to explore potential roles for activators of FOXO1 in the prevention and treatment of lung cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 21% |
| Student > Master | 6 | 18% |
| Student > Bachelor | 5 | 15% |
| Student > Ph. D. Student | 3 | 9% |
| Student > Doctoral Student | 3 | 9% |
| Other | 2 | 6% |
| Unknown | 7 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 12% |
| Medicine and Dentistry | 4 | 12% |
| Engineering | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 7 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2013.
All research outputs
#20,265,771
of 22,796,179 outputs
Outputs from Tumor Biology
#1,834
of 2,622 outputs
Outputs of similar age
#174,142
of 198,116 outputs
Outputs of similar age from Tumor Biology
#27
of 30 outputs
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So far Altmetric has tracked 2,622 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.