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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
|
|---|---|
| Published in |
Science, April 2018
|
| DOI | 10.1126/science.aao4750 |
| Pubmed ID | |
| Authors |
Mariella G Filbin, Itay Tirosh, Volker Hovestadt, McKenzie L Shaw, Leah E Escalante, Nathan D Mathewson, Cyril Neftel, Nelli Frank, Kristine Pelton, Christine M Hebert, Christine Haberler, Keren Yizhak, Johannes Gojo, Kristof Egervari, Christopher Mount, Peter van Galen, Dennis M Bonal, Quang-De Nguyen, Alexander Beck, Claire Sinai, Thomas Czech, Christian Dorfer, Liliana Goumnerova, Cinzia Lavarino, Angel M Carcaboso, Jaume Mora, Ravindra Mylvaganam, Christina C Luo, Andreas Peyrl, Mara Popović, Amedeo Azizi, Tracy T Batchelor, Matthew P Frosch, Maria Martinez-Lage, Mark W Kieran, Pratiti Bandopadhayay, Rameen Beroukhim, Gerhard Fritsch, Gad Getz, Orit Rozenblatt-Rosen, Kai W Wucherpfennig, David N Louis, Michelle Monje, Irene Slavc, Keith L Ligon, Todd R Golub, Aviv Regev, Bradley E Bernstein, Mario L Suvà |
| Abstract |
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority. OPC-like cells exhibit greater proliferation and tumor-propagating potential than their more differentiated counterparts and are at least in part sustained by PDGFRA signaling. Our study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease. |
X Demographics
The data shown below were collected from the profiles of 96 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 36 | 38% |
| Canada | 4 | 4% |
| Australia | 4 | 4% |
| United Kingdom | 4 | 4% |
| Mexico | 3 | 3% |
| France | 3 | 3% |
| Austria | 3 | 3% |
| Sweden | 2 | 2% |
| Spain | 2 | 2% |
| Other | 11 | 11% |
| Unknown | 24 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 58 | 60% |
| Scientists | 31 | 32% |
| Practitioners (doctors, other healthcare professionals) | 4 | 4% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 752 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 752 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 145 | 19% |
| Researcher | 133 | 18% |
| Student > Bachelor | 67 | 9% |
| Student > Master | 59 | 8% |
| Student > Doctoral Student | 38 | 5% |
| Other | 109 | 14% |
| Unknown | 201 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 227 | 30% |
| Agricultural and Biological Sciences | 100 | 13% |
| Medicine and Dentistry | 62 | 8% |
| Neuroscience | 44 | 6% |
| Immunology and Microbiology | 22 | 3% |
| Other | 66 | 9% |
| Unknown | 231 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 107. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2024.
All research outputs
#396,700
of 25,539,438 outputs
Outputs from Science
#10,152
of 83,080 outputs
Outputs of similar age
#8,932
of 340,919 outputs
Outputs of similar age from Science
#359
of 1,245 outputs
Altmetric has tracked 25,539,438 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,080 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,919 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,245 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.