| Title |
Older adults have delayed amino acid absorption after a high protein mixed breakfast meal
|
|---|---|
| Published in |
The journal of nutrition, health & aging, October 2015
|
| DOI | 10.1007/s12603-015-0500-5 |
| Pubmed ID | |
| Authors |
A M Milan, R F D'Souza, S Pundir, C A Pileggi, E B Thorstensen, M P G Barnett, J F Markworth, D Cameron-Smith, C J Mitchell |
| Abstract |
To measure the postprandial plasma amino acid appearance in younger and older adults following a high protein mixed meal. Cross-sectional study. Clinical research setting. Healthy men and women aged 60-75 (n=15) years, and young controls aged 20-25 years (n=15) matched for body mass index and insulin sensitivity based on the homeostatic model assessment of insulin resistance. High protein mixed meal of complete food products. Circulating amino acid concentrations were determined hourly before and for 5 hours after meal ingestion. There was no difference between cohorts in postprandial appearance of non-essential amino acids, or area under the curve of any individual amino acid or amino acid class. However, older adults had higher baseline concentrations of aspartic acid, glutamic acid, glycine, ornithine, threonine and tyrosine and lower baseline concentrations of hydroxyproline, isoleucine, leucine, methionine and valine compared to younger adults. Younger adults showed peak essential (EAA) and branched-chain amino acid (BCAA) concentrations at 1 hour post meal while older adults' peak EAA and BCAA concentration was at 3 hours. Similarly, peak total amino acid concentrations were at 3 hours in older adults. Older adults digested and absorbed the protein within a mixed meal more slowly than younger adults. Delayed absorption of AA following a mixed meal of complete food products may suppress or delay protein synthesis in senescent muscle. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 44% |
| United States | 2 | 22% |
| Spain | 1 | 11% |
| Australia | 1 | 11% |
| Italy | 1 | 11% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 56% |
| Members of the public | 4 | 44% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 20% |
| Student > Ph. D. Student | 12 | 14% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 8 | 10% |
| Student > Bachelor | 7 | 8% |
| Other | 15 | 18% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 21% |
| Nursing and Health Professions | 15 | 18% |
| Medicine and Dentistry | 13 | 15% |
| Agricultural and Biological Sciences | 11 | 13% |
| Sports and Recreations | 4 | 5% |
| Other | 5 | 6% |
| Unknown | 18 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2015.
All research outputs
#7,173,443
of 25,728,855 outputs
Outputs from The journal of nutrition, health & aging
#885
of 2,003 outputs
Outputs of similar age
#79,374
of 287,684 outputs
Outputs of similar age from The journal of nutrition, health & aging
#7
of 14 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,003 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,684 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.