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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, March 2015
|
| DOI | 10.1073/pnas.1415569112 |
| Pubmed ID | |
| Authors |
Bing Yu, Stephen Swatkoski, Alesia Holly, Liam C. Lee, Valentin Giroux, Chih-Shia Lee, Dennis Hsu, Jordan L. Smith, Garmen Yuen, Junqiu Yue, David K. Ann, R. Mark Simpson, Chad J. Creighton, William D. Figg, Marjan Gucek, Ji Luo |
| Abstract |
The small GTPase KRAS is frequently mutated in human cancer and currently there are no targeted therapies for KRAS mutant tumors. Here, we show that the small ubiquitin-like modifier (SUMO) pathway is required for KRAS-driven transformation. RNAi depletion of the SUMO E2 ligase Ubc9 suppresses 3D growth of KRAS mutant colorectal cancer cells in vitro and attenuates tumor growth in vivo. In KRAS mutant cells, a subset of proteins exhibit elevated levels of SUMOylation. Among these proteins, KAP1, CHD1, and EIF3L collectively support anchorage-independent growth, and the SUMOylation of KAP1 is necessary for its activity in this context. Thus, the SUMO pathway critically contributes to the transformed phenotype of KRAS mutant cells and Ubc9 presents a potential target for the treatment of KRAS mutant colorectal cancer. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 20% |
| Ireland | 1 | 20% |
| United States | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 40% |
| Members of the public | 2 | 40% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| France | 1 | 1% |
| Australia | 1 | 1% |
| Egypt | 1 | 1% |
| Unknown | 78 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 27% |
| Student > Ph. D. Student | 17 | 21% |
| Student > Bachelor | 8 | 10% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 3 | 4% |
| Other | 6 | 7% |
| Unknown | 19 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 27% |
| Biochemistry, Genetics and Molecular Biology | 22 | 27% |
| Medicine and Dentistry | 8 | 10% |
| Immunology and Microbiology | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 19 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2015.
All research outputs
#3,622,535
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#36,550
of 101,438 outputs
Outputs of similar age
#45,762
of 268,156 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#552
of 993 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,156 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 993 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.