| Title |
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
|
|---|---|
| Published in |
Journal of Neuroinflammation, July 2011
|
| DOI | 10.1186/1742-2094-8-79 |
| Pubmed ID | |
| Authors |
Adam D Bachstetter, Bin Xing, Lucia de Almeida, Edgardo R Dimayuga, D Martin Watterson, Linda J Van Eldik |
| Abstract |
Overproduction of proinflammatory cytokines from activated microglia has been implicated as an important contributor to pathophysiology progression in both acute and chronic neurodegenerative diseases. Therefore, it is critical to elucidate intracellular signaling pathways that are significant contributors to cytokine overproduction in microglia exposed to specific stressors, especially pathways amenable to drug interventions. The serine/threonine protein kinase p38α MAPK is a key enzyme in the parallel and convergent intracellular signaling pathways involved in stressor-induced production of IL-1β and TNFα in peripheral tissues, and is a drug development target for peripheral inflammatory diseases. However, much less is known about the quantitative importance of microglial p38α MAPK in stressor-induced cytokine overproduction, or the potential of microglial p38α MAPK to be a druggable target for CNS disorders. Therefore, we examined the contribution of microglial p38αMAPK to cytokine up-regulation, with a focus on the potential to suppress the cytokine increase by inhibition of the kinase with pharmacological or genetic approaches. |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Mexico | 1 | <1% |
| Poland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 204 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 21% |
| Student > Master | 29 | 14% |
| Student > Bachelor | 26 | 12% |
| Researcher | 24 | 11% |
| Other | 11 | 5% |
| Other | 35 | 17% |
| Unknown | 41 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 17% |
| Agricultural and Biological Sciences | 36 | 17% |
| Neuroscience | 30 | 14% |
| Biochemistry, Genetics and Molecular Biology | 29 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 6% |
| Other | 16 | 8% |
| Unknown | 50 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2020.
All research outputs
#2,916,780
of 22,653,392 outputs
Outputs from Journal of Neuroinflammation
#506
of 2,601 outputs
Outputs of similar age
#14,726
of 116,184 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 11 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,601 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,184 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.