Title |
The Kidney–Gut Axis: Implications for Nutrition Care
|
---|---|
Published in |
Journal of renal nutrition (Print), March 2015
|
DOI | 10.1053/j.jrn.2015.01.017 |
Pubmed ID | |
Authors |
Megan Rossi, David W. Johnson, Katrina L. Campbell |
Abstract |
There is increasing clinical evidence that patients with chronic kidney disease (CKD) have a distinctly dysbiotic intestinal bacterial community, termed the gut microbiota, which in turn drives a cascade of metabolic abnormalities, including uremic toxin production, inflammation, and immunosuppression, that ultimately promotes progressive kidney failure and cardiovascular disease. As the gut microbiota is intimately influenced by diet, the discovery of the kidney-gut axis has created new therapeutic opportunities for nutritional intervention. This review discusses the metabolic pathways linking dysbiotic gut microbiota with adverse health outcomes in patients with CKD, as well as novel therapeutic strategies for targeting these pathways involving dietary protein, fiber, prebiotics, probiotics, and synbiotics. These emerging nutritional interventions may ultimately lead to a paradigm shift in the conventional focus of dietary management in CKD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 33% |
South Africa | 2 | 22% |
United Kingdom | 1 | 11% |
Australia | 1 | 11% |
New Zealand | 1 | 11% |
Unknown | 1 | 11% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 4 | 44% |
Members of the public | 4 | 44% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 113 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 17% |
Researcher | 13 | 11% |
Student > Ph. D. Student | 12 | 10% |
Student > Bachelor | 9 | 8% |
Student > Doctoral Student | 9 | 8% |
Other | 26 | 23% |
Unknown | 27 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 19% |
Nursing and Health Professions | 17 | 15% |
Agricultural and Biological Sciences | 14 | 12% |
Biochemistry, Genetics and Molecular Biology | 12 | 10% |
Immunology and Microbiology | 5 | 4% |
Other | 13 | 11% |
Unknown | 32 | 28% |