↓ Skip to main content

Interleukin-34 sustains inflammatory pathways in the gut.

Overview of attention for article published in Clinical Science, May 2015
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

twitter
2 X users
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
58 Dimensions

Readers on

mendeley
42 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Interleukin-34 sustains inflammatory pathways in the gut.
Published in
Clinical Science, May 2015
DOI 10.1042/cs20150132
Pubmed ID
Authors

Eleonora Franzè, Ivan Monteleone, Maria Laura Cupi, Pamela Mancia, Flavio Caprioli, Irene Marafini, Alfredo Colantoni, Angela Ortenzi, Federica Laudisi, Giuseppe Sica, PierPaolo Sileri, Francesco Pallone, Giovanni Monteleone

Abstract

Inflammatory bowel disease (IBD)-related tissue damage occurs in areas, which are massively infiltrated with monocytes/macrophages. These cells respond to inflammatory stimuli with enhanced production of cytokines/chemokines. In this study, we analyzed the expression and role of interleukin-34 (IL-34), a regulator of monocyte/macrophage differentiation, survival and function, in IBD. A significant increase in IL-34 mRNA and protein expression was seen in inflamed mucosa of patients with Crohn's disease (CD) and patients with ulcerative colitis (UC) as compared to the uninvolved areas of the same patients and normal controls. IL-34 was up-regulated in lamina propria mononuclear cells (LPMC) isolated from normal colon by TNF-a and toll-like receptor ligands and wasdown-regulated in intestinal biopsies and LPMC of IBD patients upon treatment with Infliximab. Treatment of normal LPMC with IL-34 increased TNF-αexpression in an ERK1/2-dependent fashion and neutralization of IL-34 in IBD mucosal explants reduced TNF-α and IL-6 synthesis. In conclusion, data indicate that IL-34 is up-regulated in IBD and suggest a role for this cytokine in sustaining the inflammatory responses in this disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 19%
Student > Bachelor 7 17%
Student > Master 7 17%
Student > Ph. D. Student 6 14%
Student > Postgraduate 3 7%
Other 3 7%
Unknown 8 19%
Readers by discipline Count As %
Medicine and Dentistry 10 24%
Biochemistry, Genetics and Molecular Biology 8 19%
Agricultural and Biological Sciences 7 17%
Immunology and Microbiology 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 10%
Unknown 9 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2021.
All research outputs
#6,535,395
of 23,577,654 outputs
Outputs from Clinical Science
#599
of 2,359 outputs
Outputs of similar age
#75,534
of 265,962 outputs
Outputs of similar age from Clinical Science
#8
of 39 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,359 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,962 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.