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A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules

Overview of attention for article published in Frontiers in Bioengineering and Biotechnology, March 2015
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Title
A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules
Published in
Frontiers in Bioengineering and Biotechnology, March 2015
DOI 10.3389/fbioe.2015.00037
Pubmed ID
Authors

Giovanni Nigita, Dario Veneziano, Alfredo Ferro

Abstract

RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (adenosine-to-inosine) RNA editing, which is catalyzed by members of the adenosine deaminase acting on RNA (ADAR) family of enzymes, is the most common post-transcriptional modification in humans. The ADARs bind double-stranded regions and deaminate adenosine (A) into inosine (I), which in turn is interpreted by the translation and splicing machineries as guanosine (G). In recent years, this modification has been discovered to occur not only in coding RNAs but also in non-coding RNAs (ncRNA), such as microRNAs, small interfering RNAs, transfer RNAs, and long non-coding RNAs. This may have several consequences, such as the creation or disruption of microRNA/mRNA binding sites, and thus affect the biogenesis, stability, and target recognition properties of ncRNAs. The malfunction of the editing machinery is not surprisingly associated with various human diseases, such as neurodegenerative, cardiovascular, and carcinogenic diseases. Despite the enormous efforts made so far, the real biological function of this phenomenon, as well as the features of the ADAR substrate, in particular in non-coding RNAs, has still not been fully understood. In this work, we focus on the current knowledge of RNA editing on ncRNA molecules and provide a few examples of computational approaches to elucidate its biological function.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 3%
Chile 1 <1%
Brazil 1 <1%
Canada 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 103 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 35%
Researcher 23 21%
Student > Master 9 8%
Student > Bachelor 8 7%
Other 5 5%
Other 14 13%
Unknown 13 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 40%
Biochemistry, Genetics and Molecular Biology 33 30%
Medicine and Dentistry 5 5%
Immunology and Microbiology 3 3%
Chemistry 3 3%
Other 8 7%
Unknown 15 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2015.
All research outputs
#15,327,280
of 22,796,179 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#2,611
of 6,524 outputs
Outputs of similar age
#157,017
of 263,390 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#24
of 43 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,524 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,390 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.